Veteran western performers Harry Carey and Marguerite Clayton appeared in three films together from 1923-1924: Desert Driven, Tiger Thompson and, perhaps their best, Canyon of the Fools.

When he's fired from his bank job aimless Claude Bennett decides to head West. Once he gets a job as a cowboy on the Flying "U" ranch he restyles himself as Chip and discovers who he really is through a series of adventures.

Percival Cadwallader Perkins was so bashful that whenever a woman would look at him he would blush like a beet, and this brought the "Happy Family," the cowboys of the Flying U, to calling him "Pink."

Dennis Terhune, ranch foreman for John Morgan, an eastern capitalist, discovers that there is oil on Morgan's ranch shortly after Morgan has deeded the ranch to Daley, western manager for the Morgan properties. Dennis rides after Daley and retrieves the deed, saving Morgan's ranch and securing for himself the love of the financier's daughter, Eunice.

Montana cattleman Austin Brandt is jilted by Rosemary, who elopes with stranger Royce Greer, but he is consoled by his twenty-year-old niece Joan. Rosemary later returns to Custer City to run a dance hall with her husband, who mistreats her.

A young woman inherits her father's large Texas ranch and plans to begin a cattle drive to Abilene, Kansas, 1000 miles away. The crooked State Treasurer plans to attack the cattle drive and steal all of the stock so he can gain control of her ranch.

Agnes Cuyler, a cabaret singer in New York who loathes her work, is fired for slapping Grant Haywood, a customer from the West who tries to kiss her. Haywood begs forgiveness and after glorifying the clean Western life, proposes. To escape her circumstances, Agnes accepts, but soon learns that Haywood is a brutal drunkard.

When a cowpoke steps into a fight and saves the life of a disreputable gambler, the gambler decides to reciprocate by revealing to his new-found friend the truth about the cowpoke's fiancée.

Langley Barnes goes to the North Country to seek peace, after being deserted by his wife, and falls in love with Christine, the daughter of Angus Garth, a factor made mad by the isolation. Despite the fact that he is not divorced, Langley marries Christine in an illegal ceremony. Captain Churchill arrives to erect a radio transmitter and, returning to the United States, marries Langley's wife, who has in the interim obtained a divorce. Churchill broadcasts news of the divorce to the North Country, and Langley and Christine can now become legally married.

Chasing the man who had caused the death of his sister, Jack Walsh rescues Mary Winters from the unwanted attentions of a drunk, and learns that she has been lured to Mexico by the false promises of an ex-prizefighter "Kayo" Mooney. The latter kidnaps Mary but Jack wins the showdown and Mary, and finds that Mooney is the man he was looking for.

Buck and Charlie, two hard-boiled cowboys, arrive at the Bar Nothing Ranch in Arizona and determine to take advantage of the peculiarity of the owner, Fred Saunders, known as "Lone Hand" because he never uses his right hand.

It is California in 1852 that only recently being surrendered by Mexico to the United States and admitted into the union. Most of the land-owners of California were the descendants of the Dons who had colonized it a hundred years before and whose title deeds bore the signature and seal of a long-dead Spanish king. But, by a loop-hole in the law, the title-deeds of the Dons could not be recognized, and this opened the door of organized gangs of land-grabbers, such as the one led by Joe Kincaid, to operate with a prime excuse for legitimate plunder and robbery. In most cases the law was unable to cope with the situation. Then Rosita Castro, the daughter of Don Pasqual Castro, masked and disguised as a man, organized a band of vigilantes to fight against the tyranny of the outlaws, aided by an undercover federal agent, Jim Kearney.