Barbara Rand is blinded when she leaps through a window to escape an assailant. Her sister, Natalie, reluctantly abandons her fiancé, Ned Gardiner, and marries Oliver Landis, who can provide the money needed for Barbara's operation. Unaware that Oliver was Barbara's attacker, Natalie blames his business partner, Howard Pollard, who was with Barbara on the night she was injured. Natalie holds Howard at gunpoint, but when her husband arrives, he promises to deal with the villain making sure Howard falls to his death. Upon Barbara’s release from the hospital, Oliver tries to blind her once. Natalie threatens him with a pistol, but Oliver wrests it away from her. He then realizes that he can no longer hide his guilt from Natalie or the police and shoots himself. Barbara has been avenged, and Natalie is free to marry Ned.

Hal Whitney, an irresponsible young millionaire, befriends Timothy Payne, a wise old college professor whose life had been ruined by alcohol. After "adopting" Timothy as his father, Hal introduces him to his sweetheart, Helen Maynard. The outraged Helen breaks their engagement, certain that Timothy will be a bad influence on her hard-drinking fiancé. However, both men assist in each other's reformation, and Hal is soon reunited with Helen, while Timothy marries Hal's mother, Elizabeth, whom he had loved in his youth.

Young New York playboy Stephen Winthrop inherits the entire estate of his wealthy Canadian uncle but pays scant attention to it, preferring the "party" life in New York. He is unaware that the family attorney, Frank Garson, has forbidden hunting on the Winthrop lands in Canada, cutting off the livelihoods of the local villagers. Mary Cartier, goddaughter of the village priest, travels to New York to try to get Stephen to change the policy. He returns with her to Canada, sees what's going on, and lifts the ban, then decides to stay in Canada. Mary returns to New York to try to help Garson's abandoned and ill wife and child, but the wife dies, and Mary brings back the small child to Canada. The villagers, mistaking the child for Mary's, are outraged at this "scarlet woman" flaunting her illegitimate child and attempt to drive her out. Complications ensue.

Orphaned heiress Katherine Bradley, known as "Kit," is an orphan and heiress is attending a fashionable and select seminary for young women. A favorite of the dean, she is allowed to take her automobile for a spin every evening with the proviso that she takes a chaperone with her. Willful Kit manages to slip out alone one day and has a blowout by the roadside. Young and handsome Gerald Cameron is passing by and offers a hand. Kit and he are instantly attracted and after many complications they are finally happily united.

A young English nobleman is sent to Switzerland by his parents, where he meets a mysterious older woman with whom he has a torrid three-week romance.

A gangster running a protection racket gets information that he's about to be prosecuted on income-tax-evasion charges. He hires a man with a photographic memory to memorize his books, then destroys them all so the police won't have any evidence to link him to the racket.

George Watson may seem like a harmless gas-station attendant, but in reality he is a secret government agent, intent on ferreting out a gang of smugglers on the Mexican border.

When Jerry Van Dyke, a young debutante, decides to marry Barney, an Army corporal, whom she met at a USO dance, her family objects and consequently, the couple are unable to obtain a marriage license because Jerry doesn't come of age for four days.

Montana cattleman Austin Brandt is jilted by Rosemary, who elopes with stranger Royce Greer, but he is consoled by his twenty-year-old niece Joan. Rosemary later returns to Custer City to run a dance hall with her husband, who mistreats her.

Clay Whipple is convicted of murdering the governor following an incident involving a cat's eye pin. Whipple is sentenced to death, but a mentalist named Psychic Jack believes he is innocent since Whipple had been hypnotized at the time of the murder. The psychic persuades the judge to grant the condemned man a retrial, and he sets out to uncover the identity of the real killer, during which time he manages to prevent a second murder from occurring.

Seduced and abandoned by the caddish Louis La Farge shepherdess Marie Beaupre is cast out of the village and forced to survive in the mountains alone. Driven mad she becomes known as “the witch woman” until hypnotist Dr. Cochefort and his friend Delaunay encounter her while on a hunting trip, take her to Paris, and effectuate a cure at which time she becomes heir to Delaunay's fortune. All seems clear sailing until Marie is introduced to Louis's twin brother Maurice and mistaking him for Louis sets forth on a plan for revenge.

The Isle of Lost Men is one of those lawless tropical island colonies so beloved of adventure-story writers.