Veteran western performers Harry Carey and Marguerite Clayton appeared in three films together from 1923-1924: Desert Driven, Tiger Thompson and, perhaps their best, Canyon of the Fools.

When he's fired from his bank job aimless Claude Bennett decides to head West. Once he gets a job as a cowboy on the Flying "U" ranch he restyles himself as Chip and discovers who he really is through a series of adventures.

Percival Cadwallader Perkins was so bashful that whenever a woman would look at him he would blush like a beet, and this brought the "Happy Family," the cowboys of the Flying U, to calling him "Pink."

A cowboy arrives to help a girl who has a note due. He plans to sell her cattle to raise the money but they are stampeded and most are killed. Knowing who stampeded them gives him another plan to get the money.

Dennis Terhune, ranch foreman for John Morgan, an eastern capitalist, discovers that there is oil on Morgan's ranch shortly after Morgan has deeded the ranch to Daley, western manager for the Morgan properties. Dennis rides after Daley and retrieves the deed, saving Morgan's ranch and securing for himself the love of the financier's daughter, Eunice.

Montana cattleman Austin Brandt is jilted by Rosemary, who elopes with stranger Royce Greer, but he is consoled by his twenty-year-old niece Joan. Rosemary later returns to Custer City to run a dance hall with her husband, who mistreats her.

A young woman inherits her father's large Texas ranch and plans to begin a cattle drive to Abilene, Kansas, 1000 miles away. The crooked State Treasurer plans to attack the cattle drive and steal all of the stock so he can gain control of her ranch.

When a cowpoke steps into a fight and saves the life of a disreputable gambler, the gambler decides to reciprocate by revealing to his new-found friend the truth about the cowpoke's fiancée.

Langley Barnes goes to the North Country to seek peace, after being deserted by his wife, and falls in love with Christine, the daughter of Angus Garth, a factor made mad by the isolation. Despite the fact that he is not divorced, Langley marries Christine in an illegal ceremony. Captain Churchill arrives to erect a radio transmitter and, returning to the United States, marries Langley's wife, who has in the interim obtained a divorce. Churchill broadcasts news of the divorce to the North Country, and Langley and Christine can now become legally married.

Chasing the man who had caused the death of his sister, Jack Walsh rescues Mary Winters from the unwanted attentions of a drunk, and learns that she has been lured to Mexico by the false promises of an ex-prizefighter "Kayo" Mooney. The latter kidnaps Mary but Jack wins the showdown and Mary, and finds that Mooney is the man he was looking for.

Buck and Charlie, two hard-boiled cowboys, arrive at the Bar Nothing Ranch in Arizona and determine to take advantage of the peculiarity of the owner, Fred Saunders, known as "Lone Hand" because he never uses his right hand.

Young Scooter O’Neal, orphaned after his father’s suicide, is sent out West to live with family friend Dobe Jones. Unaware of his father’s fate Scooter longs to return to his home in Chicago especially after discovering Dobe is an embittered ranch hand hellbent on seeking revenge on his duplicitous wife Eleanor and the man she ran off with. Dobe is dogged in his pursuit until he unwittingly puts Scooter’s life in danger. Seeing the error of his ways the pair ride off together in search of a new adventure.