Veteran western performers Harry Carey and Marguerite Clayton appeared in three films together from 1923-1924: Desert Driven, Tiger Thompson and, perhaps their best, Canyon of the Fools.

Crooked gambler Eddie Kane induces his estranged wife, Poppy, to help him blackmail Brownlow Clay, the owner of a clean-cut gambling establishment in Tijuana. The plan involves Kane "discovering" Poppy in Clay's private apartment to demand hush money. During the setup, Poppy finds herself genuinely falling for Clay. Overcome with remorse and ashamed of her part in the "badger game," Poppy chooses to protect Clay and double-crosses her husband instead. With Kane's plot defeated, Poppy and Clay are free to marry and start a happy future together.

Duplicitous Patricia Chase schemes to break up the new marriage of Margery and Wallace Graham because she yearns for Wallace despite her marriage to another. She nearly succeeds but the revelation of a secret thwarts her at the last moment and she gets her just desserts shortly after.

Grace Ainsworth wants to return to her career as an opera singer, and her mother-in-law supports her. Grace's husband, Edwin, wants her to stay at home and to convince her, he relates the story of his latest play about a man who allows his wife to return to the stage. Edwin comes to believe that Grace is in love with Harold Chase, a manager, and the couple separates. Edwin has an affair with a dancer, Madeline, and he winds up in a fight with her dancing partner, Vincenti, which causes him to lose his memory.

A man is shipwrecked on a South Seas island, and although he has a fiancee back home, he falls in love with a Polynesian girl. When his fiancee finally finds him and arrives on the island to take him home, she finds out that he refuses to leave the local girl, who is now the mother of his child.

The plot concerns a war hero who returns home determined to give up his old ways as a crook. Bud Doyle (Milton Sills) is still being hounded by the cops, and both his wife (Marcia Nanon) and a former associate, a dishonest politician, want to do him in.

Jacqueline Floriot is driven from her home by her husband Louis, a deputy attorney of Paris, because of his unjust suspicions regarding her relations with another man. Floriot forbids Jacqueline to see her baby boy, who is dangerously ill, and when informed that the boy believes her dead, she attempts suicide.

In a jealous rage dancer Anna Janssen shoots her common-law husband Alastair De Vries in a cafe when she discovers him with a chorus girl. Fleeing to Tahiti she is tracked by detective Thomas McCarthy who arrests her. On their return journey they are marooned on a deserted island. After 2 years together, they realize their love and take marriage vows, but when a ship is sighted, she insists, against his wishes, that she return to face trial.

Minister John Hodder becomes rector of a prestigious church in the Midwestern city of Bremerton but finds dissension and malfeasance among his congregation. When he calls it out both tragedy and a way forward are revealed.

Barbara Rand is blinded when she leaps through a window to escape an assailant. Her sister, Natalie, reluctantly abandons her fiancé, Ned Gardiner, and marries Oliver Landis, who can provide the money needed for Barbara's operation. Unaware that Oliver was Barbara's attacker, Natalie blames his business partner, Howard Pollard, who was with Barbara on the night she was injured. Natalie holds Howard at gunpoint, but when her husband arrives, he promises to deal with the villain making sure Howard falls to his death. Upon Barbara’s release from the hospital, Oliver tries to blind her once. Natalie threatens him with a pistol, but Oliver wrests it away from her. He then realizes that he can no longer hide his guilt from Natalie or the police and shoots himself. Barbara has been avenged, and Natalie is free to marry Ned.

A gangster running a protection racket gets information that he's about to be prosecuted on income-tax-evasion charges. He hires a man with a photographic memory to memorize his books, then destroys them all so the police won't have any evidence to link him to the racket.

Montana cattleman Austin Brandt is jilted by Rosemary, who elopes with stranger Royce Greer, but he is consoled by his twenty-year-old niece Joan. Rosemary later returns to Custer City to run a dance hall with her husband, who mistreats her.