A reluctant cavalry Captain must track a defiant tribe of migrating Cheyenne.

When transplanted Texan Bob Seton arrives in Lawrence, Kansas he finds much to like about the place, especially Mary McCloud, daughter of the local banker. Politics is in the air however. It's just prior to the civil war and there is already a sharp division in the Territory as to whether it will remain slave-free. When he gets the opportunity to run for marshal, Seton finds himself running against the respected local schoolteacher, William Cantrell. Not is what it seems however. While acting as the upstanding citizen in public, Cantrell is dangerously ambitious and is prepared to do anything to make his mark, and his fortune, on the Territory. When he loses the race for marshal, he forms a group of raiders who run guns into the territory and rob and terrorize settlers throughout the territory. Eventually donning Confederate uniforms, it is left to Seton and the good citizens of Lawrence to face Cantrell and his raiders in one final clash.

After a group of convicts escapes from prison, they take refuge in the wilderness. While most of the crew are ruthless sociopaths, Jim Canfield is an innocent man who was jailed under false pretenses. When Canfield and his fellow fugitives reach an isolated farming settlement where the men are all away, it creates tension with the local women. Things get direr when rumors of hidden money arise, and Canfield discovers that the man who framed him is part of the community.

A gunhand named Lane is hired by a widow, Mrs. Lowe, to find gold stolen by her deceased husband so that she may return it and clear the family name.

Boston pharmacist Tom Craig comes to Sacramento, where he runs afoul of local political boss Britt Dawson, who exacts protection payment from the citizenry. Dawson frames Craig with poisoned medicine, but Craig redeems himself during a Gold Rush epidemic.

Duke Fergus falls for Ann 'Flaxen' Tarry in the Barbary Coast in turn-of-the-century San Francisco. He loses money to crooked gambler Boss Tito Morell, goes home, learns to gamble, and returns. After he makes a fortune, he opens his own place with Flaxen as the entertainer; but the 1906 quake destroys his place.

Viennese surgeon Dr. Braun and his daughter Leni come to a small town in North Dakota as refugees from Hitler. When the winds of the Dust Bowl threaten the town, John Phillips leads the townsfolk in moving to greener pastures in Oregon. He falls for Leni, but she is betrothed to the man who helped her and her father escape from the Third Reich. She must decide between the two men.

Karl and Kristina Nilsson work on a farm in a cold and desolate area of 19th century rural Sweden. Growing privations, combined with increasing social and religious persecution, motivate the Nilssons and many of their neighbors to strike out for the United States. Following a treacherous ocean crossing and an equally grueling land passage, the emigrants find themselves in seemingly idyllic Minnesota.

The arrival of the telegraph put Pony Express riders like John Blair and his pal Smoky out of work. A race will decide whether they or stageline owner Drake get the government mail contract.

Rockefeller is a tough and resilient man, who has spent his life as a cowboy in the Wild West, always without fear and without remorse. He is the head of a large family, which he leads with authority, sharp words and a passionate temperament. In the village, Rockefeller faces an alcoholic doctor, a wise wife, a generous-hearted girl and a sheriff who takes justice into his own hands.

A young man in New York has exasperated his father because of his constant carousing and irresponsibility, so his father sends him to his uncle's ranch in the west. The young man arrives in the town of Piute Pass, which is being terrorized by Tiger Lip Tompkins and his gang, the Masked Angels. The Easterner befriends a young woman whose father is being held captive by Tompkins, and he decides to help her.

A Tejano rancher hires an oil worker (Hank Jacobs) to pick up an artifact of the ancient world which will bring him immortal life.