It's 1876 and all the Indians are at peace except the Comanches lead by Black Cloud. When Black Cloud wipes out a town, only six soldiers are left and they head for the nearest fort. In the desert they are reinforced by members of a stagecoach and find some water at a deserted mission. Pinned down by Black Cloud they send an Indian boy who was Black Cloud's prisoner on to the fort while they try to bargain with Black Cloud whom they learn is without water.

Two down-on-their-luck former outlaws volunteer to be Texas Rangers and find themselves assigned to bring in an old friend, now a notorious outlaw.

Hoppy is busy chasing stagecoach bandits who sing as they rob.

Stagecoach robbers take the money Hoppy was going to use to buy cattle so Hoppy, California and Lin go after them.

A scruffy garbage boy becomes the pupil of famed gunfighter Talby, and the stage for confrontation is set when the gunman overruns the boy's town through violence and corruption.

A group of unlikely travelling companions find themselves on the same stagecoach to Cheyenne. They include a drunken doctor, a bar girl who's been thrown out of town, a professional gambler, a travelling liquor salesman, a banker who has decided to embezzle money, a gun-slinger out for revenge and a young woman going to join her army captain husband. All have secrets but when they are set upon by an Indian war party and then a family of outlaws, they find they must all work together if they are to stay alive.

A peace-loving man named Ben Kane takes a job as deputy marshal of Lords, in the old West. Kane is no lawman, but he accepts the badge because he has an old score to settle with the town's chief trouble-maker. Once on the job, Kane must also deal with a young sharpshooter named Billy Young and a sharp and sassy saloon dancer, Lily.

A bandit disguises himself as an officer in an attempt to woo a saloon singer.

It is now an accepted fact that the best of Johnny Mack Brown's Universal westerns were directed by the talented Joseph H. Lewis. Boss of Hangtown Mesa may not be in the same league as the Brown-Lewis classic Arizona Cyclone, but it comes awfully close. This time around, hero Steve Collins (Brown) comes to the aid of Betty Wilkins (Helen Deverell), who has taken over the telegraph-line business established by her uncle John (Henry Hall). The latter was murdered by outlaws who don't cotton to having the territory linked up electronically with the rest of the world.

A stage headed West with a group of passengers is attacked by Cheyenne Indians, and takes refuge in a nearby ghost town.

In the late 19th Century, Mary Breydon, a widow, and Peggy Breydon, her daughter manage a stagecoach stop on The Cherokee Trail. The story is told from the perspective of Peggy, looking back on her adventures.

Jim Bannon and his partner own a stagecoach line. With the coming of the telegraph and the end of the Pony Express, two men plot to take over and get the new mail contract. When Jim's partner is murdered and Jim's name is written in the sand beside the body, Jim is arrested. At his trial Whip brings surprising evidence that clears Jim and the two plotters are soon arrested.