During a blizzard in 1964, Dr. David Henry delivers his son Paul with the help of nurse Caroline. But when Henry realizes his wife is also carrying a girl with Down syndrome, he hands the second child over to Caroline without his wife's knowledge. Henry's fateful decision yields grave consequences for his family over the next 20 years.

Two brothers – one with Down syndrome, the other becoming his caregiver – deal with grief in the wake of their sister’s death. However, when their late sister’s boyfriend re-enters their lives, things take a turn for the worse, forcing both brothers to confront their familial flaws head-on.

It explores themes of love, acceptance and self-discovery through the story of two individuals, Jiro and Jessica, who have down syndrome.

A father fears the sexual awakening of his disabled son, a teenager living with Down syndrome, and struggles with the notion of letting him grow up.

Georges has Down syndrome, living at a mental-institution, Harry is a busy businessman, giving lectures for young aspiring salesmen. He is successful in his business life, but his social life is a disaster since his wife left him and took their two children with her. This weekend his children came by train to meet him, but Harry, working as always, forgot to pick them up. Neither his wife or his children want to see him again and he is driving around on the country roads, anguished and angry. He almost runs over Georges, on the run from the institution since everybody else went home with their parents except him, whose mother is dead. Harry tries to get rid of Georges but he won't leave his new friend. Eventually a special friendship forms between the two of them, a friendship which makes Harry a different person.

Inspired by an extraordinary true story, Caden Cox made history by becoming the first person with Down syndrome to play and score in a college football game.

A down-on-his-luck crab fisherman embarks on a journey to get a young man with Down syndrome to a professional wrestling school in rural North Carolina and away from the retirement home where he’s lived for the past two and a half years.

In the beginning of the 19th century, Johannes Elias Alder is born in a small village in the Austrian mountains. While growing up he is considered strange by the other villagers and discovers his love of music, especially rebuilding and playing the organ at the village church. After experiencing an "acoustic wonder", his eye color changes and he can hear even the most subtle sounds.

Happy newlyweds Ida and Jura are expecting a child. Ida suddenly finds out that the child will be special. She is unsure of how Jura will react when he learns the news, or what life with an extraordinary child will bring.

Down Quixote is a feature film adapted from the classic Don Quixote by Miguel de Cervantes, written and directed by Leonardo Cortez, with a cast made up exclusively of actors with Down Syndrome. The actors are part of the ADID Theater Group which, in 2021, completes 23 years of existence, with 12 shows inspired by classics of world dramaturgy.

At The Kingdom, Denmark's most technologically advanced hospital, a number of strange and otherworldly events begin occurring, much to the dismay of its doctors and patients. A ghostly ambulance appears and disappears, the voice of a little girl calls to a patient in an elevator shaft, and a doctor's fetus begins growing at an alarming rate.

A woman attempts to stop her daughter signing away her down syndrome grandson for adoption. Based on a true story.