Stripped of his medical license after performing an operation while high on amphetamines, famed LA surgeon Dr Eugene Sands abandons his former life only to find himself crossing paths with Raymond Blossom, an infamous counterfeiter. Employed as a "gun-shot doctor" when Raymond's associates cannot risk visiting a hospital, Eugene is lured deep into the criminal world and becomes entangled with his boss's girlfriend.

After a friend overdoses, Spoon and Stretch decide to kick their drug habits and attempt to enroll in a government detox program. Their efforts are hampered by seemingly endless red tape, as they are shuffled from one office to another while being chased by drug dealers and the police.

While investigating a young nun's rape, a corrupt New York City police detective, with a serious drug and gambling addiction, tries to change his ways and find forgiveness.

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Rick (Rutger Hauer), a disaffected sailor turned hard drinking womanizer, returns home from six months at sea to find his wife (Corrigan), whom he was deeply in love, has unexpectedly left him and is now a junkie whore. Devastated, he tries to ease his pain with booze and cheap thrills. His wife's best friend (Dagmar Lassander) makes a move on him, and when he spurns her (after scewing her first, naturally) she plots her revenge. She does so in an ingenious way, by exploiting a fantasy woman of his, but her plan backfires with tragic consequences.

Two childhood friends from South Boston turn to crime as a way to get by, ultimately causing a strain in their personal lives and their friendship.

Misunderstood by his family, abandoned by the system, and desperate for respect, a dyslexic teenager becomes a drug dealer struggling to balance his addiction and debt to a local gangster while a rival threatens to destroy his world, driving him apart from the girl he loves and a daughter he's never known.

The son of a wealthy businessman finds solace in drugs and alcohol when he breaks up with his childhood love.

A First Nations man takes a famous actor back to the reserve to help him cope with his drug addiction.

In 1973, 15-year-old William Miller's unabashed love of music and aspiration to become a rock journalist lands him an assignment from Rolling Stone magazine to interview and tour with the up-and-coming band, Stillwater.

A young police woman is faced with the difficulties between her responsibilities at work and her personal responsibilities.

A trio of female soul singers cross over to the pop charts in the early 1960s, facing their own personal struggles along the way.