Located in Madrid's Plaza del Sol, Km. 0 is the point from which all distances in Spain are measured from the capital. In Km. 0, it is also the meeting point for a gallery of characters. Bored, affluent housewife Marga meets up with gigolo Miguel, who co-habitates with gay Benjamin. Sergio, a soon-to-be-married office clerk who can't wait to lose his virginity, makes the acquaintance of prostitute Tatiana, while gay dancer Bruno meets Maximo. Meanwhile, wannabe director Pedro arranges to meet up with Silvia, an actress who wants to work in musicals directed by Gerardo, and bartender Mario is caught between Amor, who wants to marry him, and her little sister Roma, who is truly in love with him.

A homely but vivacious young woman dodges the amorous attentions of her father's middle-aged employer while attempting to please her glamorously stuck-up roommate Meredith.

Vincent and Nefeli just moved in together. They're best friends and swore to never fall in love again. That is until Vincent meets Julie.

Two co-workers, one a vain woman and the other an awkward teenager, share an increasingly bizarre relationship after becoming roommates.

Gay hair stylist Robin Turner does a lot of work for drag queens, all the while dreaming that he'll someday find the courage to perform in drag himself. When his schizophrenic friend, Liza, turns up looking for a place to stay, the two form an increasingly tight bond, Robin helping Liza through an unplanned pregnancy and Liza pushing Robin to develop a successful nightclub act.

A gay man in Soho looking for a new roommate tries to come to terms with a new reality after 9/11.

When Sara, a young design student from Iowa, arrives for college in Los Angeles, she is eager to fit in and get to know the big city. Her wealthy roommate, Rebecca, is more than eager to take Sara under her wing and show her the ropes. The two become close, but when Sara begins to branch out and make more friends on campus, Rebecca becomes resentful. Alarmed, Sara moves in with her new boyfriend, causing Rebecca's behavior to take a violent turn.

First met when they were duped by an illegal recruiter, Buddy and Sol join forces to solve a mystery that happened inside the house of the former's girlfriend.

Anna, a shy roommate, must deal with the odd demands and behavior of her roommate.

Two girls with the same name but very different personalities share an apartment in this sequel to Nana. The rising fame of Nana Osaki's band, the Black Stones, is beginning to take a toll on the best friends' relationship. Meanwhile, Nana Komatsu struggles to make sense of her love triangle with Black Stones' guitarist Nobu and rival group Trapnest's bassist Takumi.

A warped woman takes deadly measures to help a new roommate get rid of her problems.

Two roommates plan to kill a third to take advantage of college policy giving a 4.0 grade to a suicide's roommates.