Dr. Kildare treats and falls for impoverished ex-con Janet Haley, widow of a bank robber, who can't find her baby. Later she helps Kildare sew up gangster Hanlon in a tavern back room. Kildare pursues Janet and enlists Hanlon to help her; the gangster's solution, not surprisingly, is violent.

A variety of predicaments arise to distract Dr. Kildare from his wedding to Nurse Mary Lamont.

Jimmy Kildare's impending nuptials are jeopardized by a diagnosis of possible epilepsy in his fiancee's brother.

A medical school graduate takes an internship at a big city hospital, only to be subjected to a rigorous (and sometimes embarrassing) testing of his knowledge by the hospital's top dog, Dr. Leonard Gillespie.

Following an argument with his young protege, the curmudgeonly Dr. Gillespie dumps Jimmy Kildare in a street clinic, hoping to teach him a lesson. While working there Kildare meets pretty nurse Mary Lamont, and ends up treating a hoodlum with a gunshot wound. He purposely fails to write a report on it, and soon finds himself in a heap of trouble. Who else would come to his rescue but good old Dr. Gillespie?

Intern Kildare heals a millionaire's daughter and tricks Dr. Gillespie into taking a vacation.

Kildare tries brain surgery, advised by Dr. Gillespie, and faces a rival for nurse Lamont.

An ice skater sues Kildare (Lew Ayres) for malpractice after his roadside first aid leaves her paralyzed.

Dr. Gillespie supports Kildare's crusade against their hospital's deal with a rival hospital.

Mexican beauty Camilla hopes to rise above her station by marrying a wealthy American. That is complicated by meeting Arturo Bandini, a first-generation Italian hoping to land a writing career and a blue-eyed blonde on his arm.

After a one night stand with Alex, Isabel realizes that she is pregnant and they decide to get married. However, along with the marriage comes compromise of one's own cultural traditions.

In 1850s Louisiana, the willfulness of a tempestuous Southern belle threatens to destroy all who care for her.