A pathologist experiments with a deaf-mute woman who is unable to scream to prove that humans die of fright due to an organism he names The Tingler that lives within each person on the spinal cord and is suppressed only when people scream when scared.

Dr. Leon Kravaal develops a potential cure for cancer, which involves freezing the patient. But an experiment goes awry when authorities believe Kravaal has killed a patient. Kravaal freezes the officials, along with himself. Years later, they are discovered and revived in hopes that Kravaal can indeed complete his cure. But human greed and weakness compound to disrupt the project.

A ship-wrecked man floats ashore on an island in the Pacific Ocean. The island is inhabited by a scientist, Dr. Moreau, who in an experiment has turned beasts into human beings.

A group of scientists travel to a remote island to study the effects of nuclear weapons tests, only to get stranded when their airplane mysteriously explodes. The team soon discovers that the tests have given rise to crabs mutated into intelligent, impervious, telepathic giants intent on increasing their numbers by breeding, then travelling to populated areas to feed, and which do not intend to be stopped by their discoverers.

A prison ship on its way to a remote island prison runs aground on rocks and sinks. Mixed survivors of cons and prison guards struggle ashore, only to discover to their horror that another survivor got there first - the murderous & psychotic Leo Rook. Stranded, with no means of escape or call for help, the survivors must face a night of terror as they struggle to survive.

A nurse in the Caribbean turns to voodoo in hopes of curing her patient, a mindless woman whose husband she's fallen in love with.

A fishing community on a remote Maine island finds itself suddenly cut off from the rest of the world after the ferry stops coming. When people start to vanish, the terrified survivors realize that someone - or something - is hunting them.

Major Ben McBride organizes a mission to the Antarctic wastes to search for his friend who has been missing in the region for several years. McBride's party find themselves in a world populated by primitive warriors and terrifying prehistoric creatures, all of whom they must evade in order to get back safely

The residents of a suburban high-rise apartment building are infected by parasites that turn them into mindless nymphomaniac fiends.

An alien from Venus tries to take over the world with the help of a disillusioned human scientist, as his wife, his best friend and the friend's wife try to intervene.

An oceanic observation station is in desperate trouble after a sudden shark attack wrecked the oxygen supply. The accompanying ship, a coast guard cruiser, and other ships in and around the Bermuda triangle are attacked as well. The US Navy sends a submarine to investigate, but soon they too are under attack.

Americans on vacation in the Caribbean take a tour of a nearby island at night and watch a local voodoo ritual. Soon after, they find themselves stranded on the island and under attack by unseen foes. One by one they meet violent ends.