Raoul Duke and his attorney Dr. Gonzo drive a red convertible across the Mojave desert to Las Vegas with a suitcase full of drugs to cover a motorcycle race. As their consumption of drugs increases at an alarming rate, the stoned duo trash their hotel room and fear legal repercussions. Duke begins to drive back to L.A., but after an odd run-in with a cop, he returns to Sin City and continues his wild drug binge.

Chasing a memory, Alex is determined to drive cross-country to Melbourne. Planning on having just the highway for company, he reluctantly picks up a hitchhiker running from something with as much determination as Alex is running to something.

On their way to an afternoon on the lake, husband and wife Andrzej and Krystyna nearly run over a young hitchhiker. Inviting the young man onto the boat with them, Andrzej begins to subtly torment him; the hitchhiker responds by making overtures toward Krystyna. When the hitchhiker is accidentally knocked overboard, the husband's panic results in unexpected consequences.

Following the arrest of her mother, Ramona, young Vanessa Lutz decides to go in search of her estranged grandmother. On the way, she is given a ride by school counselor Bob Wolverton. During the journey, Lutz begins to realize that Bob is the notorious I-5 Killer and manages to escape by shooting him several times. Wounded but still very much alive, Bob pursues Lutz across the state in this modern retelling of Little Red Riding Hood.

One evening, Hammer gives a ride to Christina, an attractive hitchhiker on a lonely country road, who has escaped from the nearby lunatic asylum. Thugs waylay them and force his car to crash. When Hammer returns to semi-consciousness, he hears Christina being tortured until she dies. Hammer, both for vengeance and in hopes that "something big" is behind it all, decides to pursue the case.

Rick Robinson, a law intern, is scheduled to take the bar exam in just four days. Anxious to score points with his boss Mr. McAllister, Rick unwisely agrees to help the man move. The next day, Rick finds himself in a moving van from Miami to Los Angeles, accompanied by McAllister's spoiled niece and her pet pig.

The life of Al Roberts, a pianist in a New York nightclub, turns into a nightmare when he decides to hitchhike to Los Angeles to visit his girlfriend.

A sadistic serial killer terrorizes a couple driving on a rural highway in Texas while killing numerous people and framing them for his killings.

Three macabre tales from the latest issue of a boy's favorite comic book, dealing with a vengeful wooden Native American, a monstrous blob in a lake, and an undying hitchhiker.

Robert Dupea spends his days doing various odd jobs, drinking and womanizing until an encounter with his sister makes him revisit his past.

A computer expert embezzles half a million dollars and races off to Reno to start anew. Unfortunately, en route, he picks up a pair of hitchers and ends up entangled with a crazed couple who commandeer his car and leave him alone in the desert to die. As soon as he can, he hits the road to get revenge and to find his money before they do.

Roy and Gilbert's fishing trip takes a terrifying turn when the hitchhiker they pick up turns out to be a sociopath on the run from the law. He's killed before, and he lets the two know that as soon as they're no longer useful, he'll kill again. The two friends plot an escape, but the hitchhiker's peculiar physical affliction, an eye that never closes even when he sleeps, makes it impossible for them to tell when they can make a break for it.