Gentleman crook Boston Blackie answers a want ad for an expert safecracker placed by Doris Macon, who claims a moral right to the safe's contents. She hires Blackie, and they break into the house where the safe is kept. Blackie blows up the safe just as owner Captain von Hoffmeier returns home. Doris disappears with papers from inside the safe, while Blackie takes phonograph records, which, when played with a special needle, reveal secrets that implicate von Hoffmeier as a German political spy.

Based on the 1930s comic strip, The Shadow is put up against his archenemy Shiwan Khan, who plans to take over the world by holding a city to ransom using an atom bomb. Using his powers of invisibility and "the power to cloud men's minds", The Shadow comes blazing to the rescue with explosive results.

Boston Blackie is a former prison inmate campaigning to outlaw Warden Benton's infamous "Water Cross" torture. Benton, however, is successful in his attempt to have Blackie arrested and returned to the prison, but his evil schemes are ultimately thwarted by Mary Carter, Blackie's girlfriend, who manages to alert the governor. Considered a lost film.

A girl seeks revenge after a Wall Street broker had falsely accused her father and sent him unjustly to prison.

After a rare gem is stolen from an exhibition at a posh hotel, Inspector Farraday decides to recruit former thief Boston Blackie to find the stone. Along with his assistant, "The Runt", Blackie focuses his investigation on the hotel manager, George Daley, and his sister, Eileen. Through disguises and ruses, Blackie and the Runt try to trick their way to discovering the thieves.

Blackie is the natural suspect when an expensive pearl necklace is stolen while he is supposed to be guarding it.

Blackie is arrested when retrieving stolen gems from a safety deposit box for a friend.

Blackie helps the police rescue hostage from an escaped maniac on a killing spree.

Blackie performs in a magic show at a women's prison, which gives an inmate an opportunity to escape.

Blackie receives a call from a friend who asks him to retrieve some money from his apartment and deliver it to him in California. Performing this good deed, he is accused of theft, but is allowed to proceed to Hollywood to help the police find a lost diamond.

A murder is committed during the auction of a valuable statue. The prime suspect is Boston Blackie, whose reputation for living on the edge of the law makes him an easy target for the police. When the body disappears, Blackie must find it to prove his innocence.

When a murder occurs on an ocean liner docked in New York, the trail leads to Coney Island and a spy ring.