The TARDIS crew lands in the Himalayas of Cathay in 1289, their ship badly damaged, and are picked up by Marco Polo's caravan on its way along the fabled Silk Road to see the Emperor Kublai Khan. The story concerns the Doctor and his companions' attempts to thwart the machinations of Tegana, who attempts to sabotage the caravan along its travels through the Pamir Plateau and across the treacherous Gobi Desert, and ultimately to assassinate Kublai Khan in Peking, at the height of his imperial power.

The Doctor is summoned by the mysterious and powerful White Guardian, and sent on a quest to find the six segments of the Key to Time, which, once assembled, will restore balance to the Universe. Joining the Doctor and K9 is the smart and sassy Romana, a Time Lord fresh from the Academy. Landing on the wintry planet of Ribos to locate the first segment, the TARDIS crew quickly find themselves embroiled in a little local trouble with a pair of conmen and an unstable warlord...

The TARDIS materialises not far from Paris in 1794 — one of the bloodiest years following the French Revolution of 1789. The travellers become involved with an escape chain rescuing prisoners from the guillotine and get caught up in the machinations of an English undercover spy, James Stirling — alias Lemaitre, governor of the Conciergerie prison.

When the Doctor, Sarah Jane and Harry arrive in Scotland, having received an urgent request for assistance from the Brigadier, they discover that the mysterious force which has destroyed three oil rigs has left giant teeth marks on the wreckage. The mystery deepens, leading them to the shores of Loch Ness where they find that the legendary monster really does exist – and is the murderous tool of the Zygons, aliens intent on overpowering the planet. The Doctor, his companions and UNIT must find a way to defeat the deadly Loch Ness Monster and its controllers, but the Zygons have the terrifying power to change shape. The Doctor's life has never been in more danger, as the line between allies and enemies is tested to the very limit...

When the TARDIS malfunctions, it and its travellers land on Earth at the size of insects. They uncover a murderous plot involving a new insecticide, but how can they stop the crime in their miniaturised condition?

The TARDIS arrives in a desolate future London, where the Doctor discovers his old enemies the Daleks have taken control of Earth.

Erika Kohut, a sexually repressed piano teacher living with her domineering mother, meets a young man who starts romantically pursuing her.

The TARDIS arrives on the planet Marinus on an island of glass surrounded by a sea of acid. The travellers are forced by the elderly Arbitan to retrieve four of the five operating keys to a machine called the Conscience of Marinus, of which he is the keeper. These have been hidden in different locations around the planet to prevent them falling into the hands of the evil Yartek and his Voord warriors, who plan to seize the machine and use its originally benevolent mind-influencing power for their own sinister purposes.

The Doctor, Ian, Barbara and Susan arrive in the TARDIS on board a spaceship. Their initial concern is for the ship's human crew, who are suffering from telepathic interference from the Sensorites, but Susan communicates with the Sensorites and finds the aliens fear an attack by the humans and are just defending themselves. Travelling to the Sense Sphere (the Sensorites' planet) the Doctor seeks to cure an illness to which the Sensorites and Ian have succumbed, but finds it has been caused by deliberate poisoning. The political manoeuvring of the Sensorite City Administrator poses another threat to the TARDIS crew as he seeks to discredit and implicate them.

In this completely TARDIS-based story, the crew find themselves and their ship acting very strangely indeed. Blame runs high for the Ship's unusual behavior, until the Doctor realizes the TARDIS itself may be trying to warn them...

The Doctor and his companions are pursued through time and space by the Daleks on the desert planet Aridius and beyond.

The TARDIS arrives on the coast of seventeenth century Cornwall — much to the astonishment of Polly and Ben. Pirates led by Captain Samuel Pike and his henchman Cherub are searching for a hidden treasure, while a smuggling ring masterminded by the local squire is trying to off-load contraband.