Raoul Duke and his attorney Dr. Gonzo drive a red convertible across the Mojave desert to Las Vegas with a suitcase full of drugs to cover a motorcycle race. As their consumption of drugs increases at an alarming rate, the stoned duo trash their hotel room and fear legal repercussions. Duke begins to drive back to L.A., but after an odd run-in with a cop, he returns to Sin City and continues his wild drug binge.

Schoolteacher Bertram Cates is arrested for teaching his students Darwin's theory of evolution. The case receives national attention and one of the newspaper reporters, E.K. Hornbeck, arranges to bring in renowned defense attorney and atheist Henry Drummond to defend Cates. The prosecutor, Matthew Brady is a former presidential candidate, famous evangelist, and old adversary of Drummond.

Ramón Sampedro is a ship mechanic and part-time poet left a quadriplegic following a diving accident. Ramón fought for 30 years for the legal right to end his own life. He develops close relationships with his long-term lawyer Julia and his friend Rosa, who tries to convince him that his life is worth living. Despite his situation, Ramón manages to inspire those around him to live life to the fullest.

Defense attorney Martin Vail takes on jobs for money and prestige rather than any sense of the greater good. His latest case involves an altar boy, accused of brutally murdering the archbishop of Chicago. Vail finds himself up against his ex-pupil and ex-lover, but as the case progresses and the Church's dark secrets are revealed, Vail finds that what appeared a simple case takes on a darker, more dangerous aspect.

A young lawyer defends a black man accused of murdering two white men who raped his 10-year-old daughter, sparking a rebirth of the KKK.

Newly divorced lawyer Nathan Del Amico is shaken up after he meets a doctor who claims that he can sense when select people are about to die. Though he doesn't believe the doctor, events in Nathan's life slowly make him think he's not long for this world.

Rusty Sabich is a deputy prosecutor engaged in an obsessive affair with a coworker who is murdered. Soon after, he's accused of the crime. And his fight to clear his name becomes a whirlpool of lies and hidden passions.

After being shot, a lawyer loses his memory and must relearn speech and mobility, but he has a loving family to support him.

A couple struggle to find happiness after a whirlwind courtship.

After a martini-induced rampage, a fantasy-prone young woman is placed under house arrest.

A fisherman and a rising lawyer who grew up together as brothers fall in love with the same woman.

Daisy Kenyon is a Manhattan commercial artist having an affair with an arrogant and overbearing but successful lawyer and family man named Dan O'Mara. Daisy meets a single man, a war veteran named Peter Lapham, and after a brief and hesitant courtship decides to marry him, although she is still in love with Dan.