On her way by stagecoach to visit relatives out west, Flower Belle Lee is held up by a masked bandit who also takes the coach's shipment of gold. When he abducts Flower Belle and they arrive in town, Flower Belle is suspected of being in collusion with the bandit.

In the U. S. Army intelligence office, bumbling lieutenant Peter Stirling receives a coded message from his friend, Francis, a talking mule. The note urges Pete to hurry to the Coronado, California naval base, where Francis is about to be sold as surplus. Pete rushes to the train station, but before he can board, nurse Betsy Donevan mistakes him for her shell-shocked brother, Navy boatswain Slicker Donevan. She tries to forcibly remove his uniform so he will not get into trouble for impersonating an Army officer. Finally she realizes that Pete is not Slicker but merely his mirror image.

Beverly Calhoun impersonates the Prince of Graustark to claim his birthright while he recovers from a skiing injury. In the meantime, she falls for her bodyguard Dantan.

During World War II, a junior American Army officer, Lt. Peter Stirling, gets sent to the psychiatric ward whenever he insists that an Army mule named Francis speaks to him.

After a drunken night out, a longshoreman thinks he may have killed a man.

In this funny sequel to the popular Francis the Talking Mule, the talkative Mule and his pal Peter get a job working on a horse-breeder's ranch. They end up saving it from financial ruin when Francis, who has the inside track with the racehorses, provides Peter with names of the winners before the races are run. Sure enough Peter finds himself with a fistful of cash and uses it to buy a racehorse for the farm. Unfortunately, the horse he chooses is suffering from a debilitating lack of confidence. When not dealing with the mare, Peter finds time to court the horse breeder's niece and trying to avoid the gangsters who want in on the winnings.

When her fiancé is killed, dancehall queen Cleo Borden inherits his wealth. Included are oil wells overseen by British engineer Carrington, whom Cleo sets out to win by becoming a 'lady'. She horseraces in Buenos Aires, gains social position by loveless marriage to bankrupt Colton, and even performs in an opera. But when she encounters Carrington again, he's become the Earl of Stratton!

Policeman Edgar Kennedy is told by his chief he better stop a string of burglaries that have been happening on his watch or else he will get the sack. He persuades vagrants Stan and Ollie to rob the chief's house so he can regain his reputation by catching them. The policeman promises to later get the boys off. Things do not go as planned.

Bold performer Tira works as dancing beauty and lion tamer at a fair. Out of an urgent financial need, she agrees to a risky new number: she'll put her head into the lion's mouth! With this attraction, the circus makes it to New York and Tira can pursue her dearest occupation — flirting with rich men and accepting expensive presents.

Temperamental stage diva Fay Lawrence is reluctantly persuaded by a Broadway producer to star in his latest production.

Singer Rose Carlton, otherwise known as 'The San Francisco Doll', accidentally kills her controlling boyfriend when he tries to prevent her from leaving. To evade the police, Rose sets sail for Nome with captain Bull Bracket. When the ship takes on another passenger, reformer Annie Alden, Carlton's life is changed forever, and she sets out to honor a deeply personal debt.

Art film producer Jeremy Prokosch, unhappy with the work of his director, hires Fritz Lang (as himself) to direct an adaptation of The Odyssey, but when it seems that the legendary filmmaker is making a picture destined to bomb, he brings in a screenwriter to energise the script. The professional intersects with the personal when a rift develops between the writer and his wife.