Charlie and Itchy return to Earth to find Gabriel's Horn, but along the way meet up with a young boy named David, who ran away from home.

A Jewish teenager sets three goals: lose his virginity, become a writer, and survive World War II.

An Episcopal Bishop, Henry Brougham, has been working for months on the plans for an elaborate new cathedral which he hopes will be paid for primarily by a wealthy, stubborn widow. He is losing sight of his family and of why he became a churchman in the first place. Enter Dudley, an angel sent to help him. Dudley does help everyone he meets, but not necessarily in the way they would have preferred. With the exception of Henry, everyone loves him, but Henry begins to believe that Dudley is there to replace him, both at work and in his family's affections, as Christmas approaches.

Nito is a teenager with learning difficulties who has been put into a class with kids younger than him who are always mocking and playing jokes on him. Urged by the ideas they've planted in his head, Nito tries to lose his virginity.

Caroline can't stand that she is a virgin...and then the world ends. In post-apocalyptic LA, after a dust storm has wiped out the planet, she is convinced that Francis was sent as the man to pop her cherry. YOYO is a heartfelt, dark comedy about finding meaning in life, even when life ceases to exist.

Bumbling high school geek Virgil Heitmeyer has yet to lose his virginity. A golden opportunity for finally getting deflowered arises after Virgil manages to get closer to the beautiful and popular Kellie Guthrie. Will Virgil's date with Kellie go smoothly? Or is Virgil going to blow his big chance to score with the girl of his dreams?

Sister Kelly Wrath transforms from a nun with a simple temper problem to a vengeful killer. After being gunned down in an alley, she ascends to Heaven to receive training from some of the great figures of religious mythology—Moses, Gandhi, and Jesus Himself. She is sent back to Earth to join the other members of the Order of the Black Habit, a group of supernatural vigilante nuns as they seek revenge against the mob.

Good-looking but virginal "rockstar" teen Tommy tries to score with some of the local high school girls. But a classmate's mom decides to make a man out of him.

The dropout angel Candy descends to the mortal world on God's command to make the world's most miserable man, Matsutaro, happy. At work, Matsutaro is constantly yelled at by his boss, Sonoyama, but he secretly loves Mirai, who works in the same sales department, and gives her a gift. Mirai is happy, but she misunderstands the relationship between him and Candy and rejects the gift. Feeling responsible, Candy tries to correct Mirai's misunderstanding, but Mirai coldly rejects her. But deep down, Mirai also loves him.

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On his 83rd birthday, Eddie, a war vet and a maintenance worker at the Ruby Pier amusement park, dies while trying to save a girl who is sitting under a falling ride. When he awakens in the afterlife, he encounters five people with ties to his corporeal existence who help him understand the meaning of his life.

As the War in Heaven and on Earth rages on, Pyriel, the Angel of Genocide, rises to power, intending to destroy all of mankind. The only one who stands in his way is street preacher Danyael, who was born of an Angel and a woman, the nephilim.