When his cattlemen abandon him for the gold fields, rancher Wil Andersen is forced to take on a collection of young boys as his cowboys in order to get his herd to market in time to avoid financial disaster. The boys learn to do a man's job under Andersen's tutelage, however, neither he nor the boys know that a gang of cattle thieves is stalking them.

Lambert, a young man out to make his fortune, is out west trying to sell a gadget that can peel potatoes, open cans, pull out nails and perform other handy tasks. He comes to a cattle ranch and runs into a group of cowboys eating supper. He impresses the cowboys so much that they make him their leader, and it's not long before he's hired by pretty young ranch manager Vesta Philbrook as her aide and bodyguard. "The Duke", as he's now called, falls in love with her and sets out to help her get rid of a gang of vicious cattle rustlers that are constantly raiding her ranch.

Notorious shootist and womanizer Quirt Evans' horse collapses as he passes a Quaker family's home. Quirt has been wounded, and the kindly family takes him in to nurse him back to health against the advice of others. The handsome Evans quickly attracts the affections of their beautiful daughter, Penelope. He develops an affection for the family and their faith, but his troubled past follows him.

Deputy Sheriff John Steele recruits bandit Sonora Joe to help him find out who's been bumping off all the local lawmen and rustling the cattle.

When Matt Kilgore and his men frame and then hang an innocent man, Lige Saunders sends for his son Wild Bill Saunders who arrives to find his father shot by Matt's brother. When the brother is killed in his fight with Bill, Matt sends two fake Deputies to arrest Bill whom he then plans to hang. But Matt's sister, attracted to Bill, overhears the plan and rides for help.

Hoppy is busy chasing stagecoach bandits who sing as they rob.

Lee Garvin has eloped with the daughter of a railroad man who didn't approve of the marriage. Hoppy steps in when the young man is framed for murder.

European bad guy Baron Bendor leads some local townsmen in a plot to obtain horses through theft. Hoppy and his sidekicks Lucky and Speedy must find and expose the horse thieves.

Hopalong Cassidy and Johnny Nelson ride to the mountains to help a man and his daughter save their logging business from someone who is sabotaging their efforts.

Posing as a cattle buyer, Hoppy crosses over into Oklahoma where the Jordan brother's and their outlaw gang operate outside the law. After receiving an unfriendly reception when he finds them, he, California, and Johnny rustle their cattle and drive across the river into Texas. He hopes they will cross over to retrieve their cattle and then he can arrest them.

Hoppy is leading a scientific expedition and the Chinese who have a hidden settlement nearby are trying to stop them. Saulters and his outlaw gang are also in the area looking for a gold mine. When Saulters men attack, the gold mine is found. Hoppy agrees to file for the Chinese and heads after Saulters in the chase to the land office.

Hoppy's ranch is threatened by rustlers. Hoppy and the gang oblige as usual.