Fidencio Borer, an apothecary in a village on the northern border of Mexico, discovers some old title of a mine in Arizona and decides to claim them. Trying to cross the border is a border guard intercepted by exaggerating in the line of duty. On the way is captured by a tribe of Apaches and is about to be burned alive, but thanks to the Great Head Horse Lying having toothache and learns that the prisoner it can heal, ordered his release on the condition that the cure. Fidencio would take the wheel and gets the eternal friendship of the Chief apache.

Bob Ford murders his best friend Jesse James in order to obtain a pardon that will free him to marry his girlfriend Cynthy. The guilt-stricken Ford soon finds himself greeted with derision and open mockery throughout town. He travels to Colorado to try his hand at prospecting in hopes that marriage with Cynthy is still in the cards.

With the California Gold Rush beginning, Senator Frost's singing daughter Caroline loves a young army officer; the Senator can't stand him, and has him sent to California. Headstrong Caroline follows him by train, riverboat, and covered wagon, gaining companions en route: a vagrant Russian prince and gambler Johnny Lawlor, who just might take her mind off the army.

A grizzled ex-sheriff helps a man framed for murder to confront the powerful trio of brothers who want him dead.

After his cattle rancher boss dies, right-hand man Pike is given the job of returning $86,000 to some families who live across the border in Sonora, Mexico. Honest Pike is joined on the trip through the wilderness by a dishonest gambler named Tyree.

Hoppy and his pals arrive in a remote town to investigate the counterfeiting of both U.S. and Mexican money; his only clues are the name "Mordigan" and a drawing of a comet. He quickly finds out that Mordigan is the town "boss"; but what or who is "the comet", and why are Mordigan and his henchmen intent on persecuting a young woman, her drunken brother, and her deathly ill sister-in-law who've also just arrived in town?

Saloon-bar singer Freddie gets very angry whenever boyfriend Blackie seems to be playing around. She always packs a six-shooter, so this is bad news for anything that happens to be in the way. As this is usually the local judge's rear-end, Freddie and friend Conchita are soon hiding out teaching school in the middle of nowhere.

Goss, Mason, and Kelly force Joaquin Murieta to watch as they hang his brother Juan for a crime he did not commit. To exact his revenge on the three, Joaquin becomes the notorious Black Shadow.

Monte Walsh and Chet Rollins are long-time cowhands, working whatever ranch work comes their way, but "nothing they can't do from a horse." Their lives are divided between months on the range and the occasional trip into town. Monte has a long-term relationship with prostitute Martine Bernard, while Chet has fallen under the spell of the widow who owns the hardware store. Camaraderie and competition with the other cowboys fill their days, until one of the hands, Shorty Austin, loses his job and gets involved in rustling and killing. Then Monte and Chet find that their lives on the range are inexorably redirected.

A town—where everyone seems to be named Johnson—stands in the way of the railroad. In order to grab their land, robber baron Hedley Lamarr sends his henchmen to make life in the town unbearable. After the sheriff is killed, the town demands a new sheriff from the Governor, so Hedley convinces him to send the town the first black sheriff in the west.

Lucky Luke becomes the Sheriff of Daisy Town and runs out all the criminals. Then the Dalton brothers arrive and try to get the Indians to break the peace treaty and attack the town.

Fuzzy purchases a saloon with a large sack of gold from the mine he owns with his partner Billy. When a crooked lawyer uses underhanded methods to try taking over the saloon, Billy works to bring the lawyer and his no-good gang to justice.