While driving through the New Mexico Desert during a rainy night, college students Jim Halsey and his girlfriend Grace Andrews give a ride to a hitchhiker. While in their car, the stranger proves to be a psychopath threatening the young couple with a knife, but Jim successfully throws him out of the car. This sets off a chain of events that will change all of their lives forever.

Thomas hitchhikes from Hamburg to Munich where he meets his ex-girlfriend, Peggy. Thomas doesn't have a bed for the night and goes home with Peggy, not knowing that she and her four roommates have all made a strange pact.

One evening, Hammer gives a ride to Christina, an attractive hitchhiker on a lonely country road, who has escaped from the nearby lunatic asylum. Thugs waylay them and force his car to crash. When Hammer returns to semi-consciousness, he hears Christina being tortured until she dies. Hammer, both for vengeance and in hopes that "something big" is behind it all, decides to pursue the case.

Joe and Paul Fabrini are Wildcat, or independent, truck drivers who have their own small one-truck business. The Fabrini boys constantly battle distributors, rivals and loan collectors, while trying to make a success of their transport company.

A computer expert embezzles half a million dollars and races off to Reno to start anew. Unfortunately, en route, he picks up a pair of hitchers and ends up entangled with a crazed couple who commandeer his car and leave him alone in the desert to die. As soon as he can, he hits the road to get revenge and to find his money before they do.

A young woman stumbles into a nightmare land of hijacking and humiliation while driving cross-country from California to New York.

In this Franco-Italian gangster parody, a shopkeeper on his way to an Italian holiday suffers a crash that totals his car. The culprit can only compensate his ruined trip by driving an American friend's car from Naples to Bordeaux, but as it happens to be filled with such contraband as stolen money, jewelry and drugs, the involuntary and unwitting companions in crime soon attract all but recreational attention from the "milieu".

A bickering couple driving cross-country through California pick up a psychotic hitchhiker with two million dollars who threatens to kill them unless they take him to Mexico.

Set in 1964, a three-day journey along Route 66 begins when Bobby Falls, a 19-year-old serial killer, hitches a ride with Jim Goodwin, a celebrity animal handler travelling with his precious cargo: his TV chimpanzee, Spanky.

Kowalski works for a car delivery service, and takes delivery of a 1970 Dodge Challenger to drive from Colorado to San Francisco. Shortly after pickup, he takes a bet to get the car there in less than 15 hours.

Following the arrest of her mother, Ramona, young Vanessa Lutz decides to go in search of her estranged grandmother. On the way, she is given a ride by school counselor Bob Wolverton. During the journey, Lutz begins to realize that Bob is the notorious I-5 Killer and manages to escape by shooting him several times. Wounded but still very much alive, Bob pursues Lutz across the state in this modern retelling of Little Red Riding Hood.

Howard is mild-mannered and slightly simple-minded, with a habit of picking up teenage hitchhikers while driving his delivery routes. Sometimes the girls admit to being runaways, and if they claim to hate their mothers it drives Howard into a violent frenzy; his sister ran away from home years ago and was never heard from again, causing his desperate, addled mother to tighten her hold on him. Howard never remembers raping his victims or strangling them with wire coat hangers, though his boss does notice missed deliveries and late arrivals.