Rancher Rex Allen receives a summons from his uncle. an old time frontiersman, that he is in trouble. The uncle has been hired to lead a modern-day band of adventurers on a wagon train retracing the route taken by their ancestors 100 years ago. Before Rex can talk to his uncle, the uncle is murdered, and Rex sets out to find the killer and the motive by taking his uncle's place as the leader of the wagon train.

Buck Roberts is leading a wagon train of railroad supplies and Jim Corkle and his henchman Loder are out to stop them by using white men dressed as Indians for the attacks.

Four unwitting heroes cross paths on their journey to the sleepy town of Silverado. Little do they know the town where their family and friends reside has been taken over by a corrupt sheriff and a murderous posse. It's up to the sharp-shooting foursome to save the day, but first they have to break each other out of jail, and learn who their real friends are.

Sent by the Army, Andy Thomas poses as a renegade to find out who has been harassing the wagon trains.

A wagon train heads for Denver with a cargo of whisky for the miners. Chaos ensues as the Temperance League, the US cavalry, the miners and the local Indians all try to take control of the valuable cargo.

In 1846, a reporter for the New York Herald joins a wagon train bound for the Oregon Territory. He hopes to confirm a rumor that President Polk is sending in soldiers disguised as settlers in order to strengthen American claims to the Territory.

A portrayal of the early Latter-day Saints' joys, sacrifices, hopes, and trials; their epic journey to the Salt Lake Valley; and their legacy of faith in Jesus Christ.

Bill, who is about to lead a wagon train to California, has a map to a valuable gold field and Rocky is after the map. When Rocky and his men attack, Ken Manning breaks it up and later identifies Rocky and his men as the attackers. Expelled from the wagon train, they stampede a buffalo herd puting the Indians on the warpath. After the Indians attack the wagon train, Rocky thinks he can get the map.

A western settlement of pioneer descendants is threatened with the loss of its water supply through the encroachments of nearby townspeople.

Nineteen year old pioneer woman Marty has recently married. She goes west with her husband Clem, hoping to start a new life. But Clem unexpectedly dies, and Marty finds herself alone, two months pregnant. Widower Clark offers her a marriage of convenience: she needs food and money, and he needs someone to take care of his daughter Missie. She accepts his proposal as a temporary solution.

The wagon train on the way to Kentucky has to lighten the loads to get across the mountains and battle Indians.

The Johnny Mack Brown West of Wyoming concerns the efforts by cattle baron Simon (Stanley Andrews) to prevent the opening up of the rang to homesteaders. Government agent Brown comes calling when Simon begins resorting to cold-blooded murder. The leading lady is Gail Davis, a few years shy of her Annie Oakley TV stardom. Surprisingly, West of Wyoming contains none of the comedy relief that had characterized earlier Johnny Mack Brown oaters.