Old Mexican-American sheriff Bob Valdez has always been a haven of sanity in a land of madmen when it came to defending law and order. But the weapon smuggler Frank Tanner is greedy and impulsive. When Tanner provokes a shooting that causes the death of an innocent man and Valdez asks him to financially compensate the widow, Tanner refuses to do so and severely humiliates Valdez, who will do justice and avenge his honor, no matter what it takes.

At the height of the frontier era, a train races through the Rocky Mountains on a classified mission to a remote army post. But one by one the passengers are being murdered, and their only hope is the mysterious John Deakin, who's being transported to face trial for murder.

Daniel Bone is aiming for success. A Brooklyn gunsmith by trade, he figures the place to be is where the guns are. So off he goes into the West and becomes the foe of the notorious Pecos Kid, the captive of Paiutes, the target in a saloon showdown, and the lone source of the whereabouts of a fabulous gold strike.

A Mexican bandit is about to be executed in the United States, so his brother takes over a train and holds the passengers as hostages unless his brother is released. Now both the Americans and Mexicans are baffled as to what to do. One of the passengers — who wrote the letter for their captor — has a suggestion: call mercenaries Hank Brackett and Johnny Reech. They do, and as expected they do come up with a plan, but the president of the railroad is not sure if it will work.

A group of people traveling on a stagecoach find their journey complicated by the threat of Geronimo, and learn something about each other in the process.

Pat Garrett is hired as a lawman on behalf of a group of wealthy New Mexico cattle barons to bring down his old friend Billy the Kid.

Buck Duane is on the run after killing his father's murderer. He rescues a beautiful young woman from an outlaw, but the outlaw's wife has eyes for the young cowpoke and makes trouble for him.

John Found, a well-educated American Indian, works as an interpreter on an army post in the West. Although John Lane, a post officer, loves Katie O'Day, a rancher's daughter, he becomes the amorous target of the widowed Mrs. Van Allen. To rid herself of Katie, Mrs. Van Allen starts a rumor that Lane has a wife in an insane asylum.

After escaping from jail, outlaw Wes McQueen is convinced by his old partner in crime to do one last heist.

On a train trip out west to become a mail-order bride, Susan Bradley meets a cheery crew of young women traveling out to open a "Harvey House" restaurant at a remote whistle-stop.

The hunter becomes the hunted, an officer of the Royal Mounted, fleeing, fighting for his life. Guided to a secret valley in the frozen North by a hot-blooded French-Canadian beauty, with a secret of her own...

Dan Evans, a small time farmer, is hired to escort Ben Wade, a dangerous outlaw, to Yuma. As Evans and Wade wait for the 3:10 train to Yuma, Wade's gang is racing to free him.