When car dealer Charlie Babbitt learns that his estranged father has died, he returns home to Cincinnati, where he discovers that he has a savant older brother named Raymond and that his father's $3 million fortune is being left to the mental institution in which Raymond lives. Motivated by his father's money, Charlie checks Raymond out of the facility in order to return with him to Los Angeles. The brothers' cross-country trip ends up changing both their lives.

Former A. E. F. boxing champion Tom Harper, who suffered gas poisoning, is sent to the mountains to regain his health so that he can re-enter the ring and earn the money needed for his crippled sister's operation. Under strict orders not to exert himself, Tom allows himself to be beaten up by Phillip Brand, the town bully, in front of his girl, Harriet Monroe.

After a body-altering accident, a woman must find a way forward in her new reality.

Tsukasa got into a severe car accident when she was a high school student. She still suffers from the effects of that accident, with memory impairment and needing to use a wheelchair. Tsukasa falls in love with taxi driver Masaki. Even though they have difficulties, they try to make a happy family together, but they encounter another serious situation.

In 19th-century Italy, Giacomo Leopardi channels his debilitating illness and isolation into poetry.

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Patrick (bitter wheelchair user) must enlist the help of his cantankerous neighbor Robert (double amputee veteran) to transport the four-year-old daughter he never knew he had to live with her maternal grandparents on the other side of the country.

For revenge, wealthy Osbert Gault marries Virginia Mynors, the daughter of a woman who had jilted him years earlier. Unaware of Gault's motives, Virginia consents to the marriage for the sake of her impoverished family.

Hazuki and Aoi are classmates but their relationship outside class is fraught, and outside school non-existent. But when both girls are drawn to helping an elderly woman, they're forced to interact, confronting their differences and similarities as well as their deepest secrets.

After a crippling injury leaves her husband impotent, Lady Chatterly is torn between her love for her husband and her physical desires. With her husband's consent, she seeks out other means of fulfilling her needs.

A down-on-his-luck crab fisherman embarks on a journey to get a young man with Down syndrome to a professional wrestling school in rural North Carolina and away from the retirement home where he’s lived for the past two and a half years.

Rizwan Khan, a Muslim from the Borivali section of Mumbai, has Asperger's syndrome. He marries a Hindu single mother, Mandira, in San Francisco. After 9/11, Rizwan is detained by authorities at LAX who treat him as a terrorist because of his condition and his race.