In Los Angeles, Max Carlyle makes a good living directing commercials and has a happy home life with his wife, Mimi, and two children. When Carlyle travels to New York City to visit his friend Charlie, who has been diagnosed with AIDS, he has repeat run-ins with a beautiful woman, Karen, and eventually sleeps with her. Though he goes home the next day and doesn't return until a year later, Carlyle's infidelity still lingers.

After a friend overdoses, Spoon and Stretch decide to kick their drug habits and attempt to enroll in a government detox program. Their efforts are hampered by seemingly endless red tape, as they are shuffled from one office to another while being chased by drug dealers and the police.

16-year old Jan is absent-mindedly strolling through the streets when he's run over by roller-skating Nina. As fast as she has stormed into his life, however, she rushes off again. Nina is 15 years old and full of crazy ideas. She lives together with her brother, her father and his new girlfriend. Her mother isn't in touch much. That's why there is the unconventional Angel whose own daughter disappeared years ago and who is Nina's best friend and substitute mother.

A young Donald Trump, eager to make his name as a hungry scion of a wealthy family in 1970s New York, comes under the spell of Roy Cohn, the cutthroat attorney who would help create the Donald Trump we know today. Cohn sees in Trump the perfect protégé—someone with raw ambition, a hunger for success, and a willingness to do whatever it takes to win.

When 19-year-old gay-rights activist Tommy and 24-year-old Alan first meet in 1973, they find themselves on the opposite sides of the political coin...

In a vibrant tapestry of love and longing, nine interconnected souls navigate romance and heartbreak in L.A., where passions collide and truths unfold, revealing that the heart's desires often lead us where we least expect.

Caye is a young prostitute whose family is unaware of her profession. She meets her striking Dominican neighbour Zulema, an illegal immigrant, after she finds her in the bathroom, badly beaten up. They strike up a close friendship unbeknownst to Caye's xenophobic co-workers.

Claudio, a womanizer, contracts AIDS due to his promiscuous lifestyle, and, in the hospital, he meets Mauricio, a homosexual Evangelist who is also infected and will discover Jesus to Claudio.

Erik, a loner, finds a friend in Dexter, an eleven-year-old boy with AIDS. They vow to find a cure for AIDS together and save Dexter's life in an eventful summer.

After falling ill, Yesterday learns that she is HIV positive. With her husband in denial and young daughter to tend to, Yesterday's one goal is to live long enough to see her child go to school.

In Uganda, AIDS-infected mothers have begun writing what they call Memory Books for their children. Aware of the illness, it is a way for the family to come to terms with the inevitable death that it faces. Hopelessness and desperation are confronted through the collaborative effort of remembering and recording, a process that inspires unexpected strength and even solace in the face of death.

Spanning several decades, this powerful biopic offers a glimpse into the life of famed Cuban poet and novelist Reinaldo Arenas, an artist who was vilified for his homosexuality in Fidel Castro's Cuba.