An ex-con seeks revenge on the man who put him in prison by planning a robbery of the latter's stagecoach, which is transporting gold. He enlists the help of a partner, who could be working for his nemesis.

Rancher Rex Allen receives a summons from his uncle. an old time frontiersman, that he is in trouble. The uncle has been hired to lead a modern-day band of adventurers on a wagon train retracing the route taken by their ancestors 100 years ago. Before Rex can talk to his uncle, the uncle is murdered, and Rex sets out to find the killer and the motive by taking his uncle's place as the leader of the wagon train.

When young Crazy Horse, of whom great things were predicted, wins his bride, rival Little Big Man goes to villainous traders with evidence of gold in the sacred Lakota burial ground. Of course, a new gold rush starts despite all treaties, and Crazy Horse becomes military leader of his people. Initial Indian victories lead to the inevitable result. Uniquely, all is told from the Indian perspective.

Anita Morell arrives by stagecoach in a small California town to find her father murdered and his property being stolen by two unscrupulous townsmen. She receives help from a sympathetic lawman and from a masked rider known as "the Black Shadow" whose whip-scarred back is evidence of his own grudge against the townsmen.

Buck Roberts is leading a wagon train of railroad supplies and Jim Corkle and his henchman Loder are out to stop them by using white men dressed as Indians for the attacks.

Oregon, 1851. Hermann Kermit Warm, a chemist and aspiring gold prospector, keeps a profitable secret that the Commodore wants to know, so he sends the Sisters brothers, two notorious assassins, to capture him on his way to California.

After striking gold in Alaska, the romantic George sends his womanizing partner Sam to bring his fiancée up from Seattle. When Sam finds that she has already married, he returns instead with Angel, a dancer originally from France.

Four unwitting heroes cross paths on their journey to the sleepy town of Silverado. Little do they know the town where their family and friends reside has been taken over by a corrupt sheriff and a murderous posse. It's up to the sharp-shooting foursome to save the day, but first they have to break each other out of jail, and learn who their real friends are.

Sent by the Army, Andy Thomas poses as a renegade to find out who has been harassing the wagon trains.

Two con-men from the East come out West to join up with Avery. They plan to steal the Lopez diamond from Don Lopez. With the drought, Lopez has sold all of his other jewels for gold so that he can take his people to a better place to live and work. Dean and Soapy try to protect Lopez, but Avery and his gang steal the gold and look forward to stealing the diamond necklace. When Maria offers to become partners with Barrit, it looks bad for Lopez.

A wagon train heads for Denver with a cargo of whisky for the miners. Chaos ensues as the Temperance League, the US cavalry, the miners and the local Indians all try to take control of the valuable cargo.

In 1846, a reporter for the New York Herald joins a wagon train bound for the Oregon Territory. He hopes to confirm a rumor that President Polk is sending in soldiers disguised as settlers in order to strengthen American claims to the Territory.