Jim Bannon and his partner own a stagecoach line. With the coming of the telegraph and the end of the Pony Express, two men plot to take over and get the new mail contract. When Jim's partner is murdered and Jim's name is written in the sand beside the body, Jim is arrested. At his trial Whip brings surprising evidence that clears Jim and the two plotters are soon arrested.

In the late 19th Century, Mary Breydon, a widow, and Peggy Breydon, her daughter manage a stagecoach stop on The Cherokee Trail. The story is told from the perspective of Peggy, looking back on her adventures.

John Russell, disdained by his "respectable" fellow stagecoach passengers because he was raised by Indians, becomes their only hope for survival when they are set upon by outlaws.

Two investigators for a stagecoach company are assigned to find out why the company's stages keep being ambushed. They discover that the culprits are white men disguised as Indians, and they set out to discover who is behind the plot.

Dan Evans, a small time farmer, is hired to escort Ben Wade, a dangerous outlaw, to Yuma. As Evans and Wade wait for the 3:10 train to Yuma, Wade's gang is racing to free him.

Jesse W. Haywood (Don Knotts) graduates from dental school in Philadelphia in 1870 and goes west to become a frontier dentist. Penelope "Bad Penny" Cushing (Barbara Rhoades) is offered a pardon if she will track down a ring of gun smugglers. She tricks Haywood into a sham marriage as a disguise. Haywood inadvertently becomes the legendary "Doc the Haywood" after he guns down "Arnold the Kid".

U.S. Marshals "Nevada Jack" McKenzie and "Sandy" Hopkins, working undercover, investigate a plot to rob a widow and her daughter of a mine which they know to be filled with gold-laden ore, but the widow believes it has played out. A hermit, hanging around the mine and killing, impartially, anyone who enters the mine, impedes the investigation somewhat.

In order to obtain a stage coach mail contract, a new road must be built. A gang of outlaws try to prevent the building of the road.

Wilson and his saddle pal Andy Clyde come to the rescue of a group of ranchers who are being victimized by villain Ace Larabee (Douglas Kennedy). Ace has inside information that the railroad is coming through the territory, and he intends to grab up all the land and sell it to the train execs for a tidy profit.

A mysterious preacher protects a humble prospector village from a greedy mining company trying to encroach on their land.

Questions arise when Senator Stoddard attends the funeral of a local man named Tom Doniphon in a small Western town. Flashing back, we learn Doniphon saved Stoddard, then a lawyer, when he was roughed up by a crew of outlaws terrorizing the town, led by Liberty Valance. As the territory's safety hung in the balance, Doniphon and Stoddard, two of the only people standing up to him, proved to be very important, but different, foes to Valance.

Three lawmen hunt down thieves who are robbing a tungsten mine.