Jim Bannon and his partner own a stagecoach line. With the coming of the telegraph and the end of the Pony Express, two men plot to take over and get the new mail contract. When Jim's partner is murdered and Jim's name is written in the sand beside the body, Jim is arrested. At his trial Whip brings surprising evidence that clears Jim and the two plotters are soon arrested.

In the late 19th Century, Mary Breydon, a widow, and Peggy Breydon, her daughter manage a stagecoach stop on The Cherokee Trail. The story is told from the perspective of Peggy, looking back on her adventures.

John Russell, disdained by his "respectable" fellow stagecoach passengers because he was raised by Indians, becomes their only hope for survival when they are set upon by outlaws.

Ranger Job "Blue Streak" McCoy helps a miner and his pretty young daughter who are trying to protect their valuable mine from a gang leader who wants to take it.

Two investigators for a stagecoach company are assigned to find out why the company's stages keep being ambushed. They discover that the culprits are white men disguised as Indians, and they set out to discover who is behind the plot.

Dan Evans, a small time farmer, is hired to escort Ben Wade, a dangerous outlaw, to Yuma. As Evans and Wade wait for the 3:10 train to Yuma, Wade's gang is racing to free him.

Jesse W. Haywood (Don Knotts) graduates from dental school in Philadelphia in 1870 and goes west to become a frontier dentist. Penelope "Bad Penny" Cushing (Barbara Rhoades) is offered a pardon if she will track down a ring of gun smugglers. She tricks Haywood into a sham marriage as a disguise. Haywood inadvertently becomes the legendary "Doc the Haywood" after he guns down "Arnold the Kid".

Lean, mean Texas Ranger Jack Benteen locks horns with a former friend, Cash Bailey, now a ruthless drug kingpin. Though they're on opposite sides of the law, they share a love interest in the sensual Sarita. When a crew of rogue soldiers descends upon the border town for an off-the-books mission, all roads lead to a bloody, to-the-death showdown, as loyalties shift and the lines between good and evil are blurred.

On the American frontier in the last decades of the 19th century, Billie is a female cowboy who fights a series of bad men in this film serial.

An aging group of outlaws look for one last big score as the "traditional" American West is disappearing around them.

An ex-convict (Bob Steele) returns to his ranch; he and his sidekick (Sid Saylor) prove he was framed.

In order to obtain a stage coach mail contract, a new road must be built. A gang of outlaws try to prevent the building of the road.