The Prairie is set at the time of the Louisiana Purchase. Hoping to find their destiny in the new territory, the Bush Family heads southward in a covered wagon. Sharing the family's numerous dangers and hardships are Ellen Wade (Lenore Aubert), sole survivor of an Indian attack, and army mapmaker Paul Hover (Alan Baxter). Cousins Abiram (Russ Vincent) and Asa (Jack Mitchum) duke it out over Ellen's affections

An outlaw decides to hang up his guns and lead the "straight" life. His foster son falls for the daughter of a wealthy estate owner. The crooked manager of the estate wants the girl for himself--so he can control the estate when the father dies--and tells the father that the boy is an outlaw's son.

Our hero is mistaken for a bandit. Al's girl Nancy at first believes him to be guilty, but he manage to convince her that the real bandit is McDonald.

In this Western, Frank Keenan has a dual role -- kind-hearted gambler John Lynch and evil bandit Big Rivers. The only person who realizes there is a resemblance between the two is dance hall girl Nita (Maude George), who was abused by the outlaw and cared for by Lynch.

Bill Merritt and his pal, Chewin' Charlie, notice a touring car passing them on the road. Soon the car stops, and the party sets out after a jackrabbit wanted by an elderly lady in the car. Bill, realizing the brakes have slipped on a downgrade, rescues the runaway car and its occupant, Mrs. Gordon, and wins the lady's admiration. Invited to the hotel of millionaire mine owner Andrew Gordon, Bill becomes interested in his daughter, Cleo, but is told that the man who aspires to be her husband must possess wealth. That night Bill overhears a plot to take over a strip of land between Gordon's mine and that of his enemy Tom Middleton; Bill and Charlie set out to stake their claim, and after subduing "Fraction" Jack, they register the claim. Bill persuades Gordon to buy out his claim and saves Charlie from claim jumpers.

Bill Drake is a cowpoke who must prove himself innocent of robbing the general store. The real culprit, as our hero detects, is Tom Evans, the weakling son of a local rancher.

Gold miner Edd Denmeade loves Lucy Watson, the sister of the official mining claim recorder. Denmeade suspects Watson of killing his father, who after a poker game was shot by a gambler "who shuffles with one hand." The real murderer, Sam Spralls, has convinced Watson that he killed Denmeade and threatens to expose him unless Watson assigns him all the gold claims. Spralls assembles a band of killers to jump the claims when Watson complies. Eventually, Denmeade learns the identity of the killer when he sees Spralls shuffle a deck of cards. He forms a vigilante party and rids the community of Spralls and his gang.

A college graduate returns West after ten years in the East to her home in Sulfur Springs. Virginia's mother, the owner of a rooming house has turned hard and uncaring in her absence and the girl finds comfort in her friendship with Ross Cavanagh, a forest ranger. The latter runs afoul of cattle baron Sam Gregg, who resents a new tax on cattle grazing on government land.

On the American frontier in the last decades of the 19th century, Billie is a female cowboy who fights a series of bad men in this film serial.

Trying to trick Ma (Lydia Knott) and Mary Winters (Allene Ray) into selling their rundown ranch, which will be in the path of a future railroad, Underwood (Charles K.French) hires Keno Creager (Albert Smith) to impersonate Jimmy Winters, not seen by his mother and sister for many years.

Miner Dan Stuyvesant finally strikes it rich, but on his way to report his claim, he is shot. When Jack Dedlow, the head of a gang of outlaws, hears this news, he rides to Stuyvesant's cabin intending to secure the claim for himself. There the outlaws find Stuyvesant's daughter Hilda, the sweetheart of Tom Flynn, and are about to draw cards for her when Dago Sam pulls out his guns and spirits her out the door. Because Tom is his only friend, Sam determines to protect Hilda from the gang, but when Tom suspiciously questions his intentions toward Hilda, Sam decides to live up to the town's poor opinion of him.

Jack Darling of the North West Mounted Police is ordered to track down and arrest murderer Alec Young, whose girl, Dancing Pete, performs in the Nugget dance hall. En route to Nugget, Jack meets Hope Ross, who is caring for her sister's baby. Although the two fall in love, the outlook for a happy romance appears hopeless, because he believes that she is a married mother, and she thinks that he is an outlaw.