Dr. Frankenstein and his monster both turn out to be alive after being attacked by an angry mob. The now-chastened scientist attempts to escape his past, but a former mentor forces him to assist with the creation of a new creature.

Famed monster slayer Gabriel Van Helsing is dispatched to Transylvania to assist the last of the Valerious bloodline in defeating Count Dracula. Anna Valerious reveals that Dracula has formed an unholy alliance with Dr. Frankenstein's monster and is hell-bent on exacting a centuries-old curse on her family.

Frankenstein, a young medical student, trying to create the perfect human being, instead creates a misshapen monster. Made ill by what he has done, Frankenstein is comforted by his fiancée; but on his wedding night he is visited by the monster.

Henry Frankenstein pieces together body parts in the hope of bringing a human-like creature to life. The mad scientist’s dreams are shattered by his monstrous creation awakening with rage to a world that hates and fears him.

The Wolf Man tries to warn a dimwitted porter that Dracula wants his brain for Frankenstein monster's body.

Frankenstein's unscrupulous colleague, Dr. Bohmer, plans to transplant Ygor's brain so he can rule the world using the monster's body, but the plan goes sour when he turns malevolent and goes on a rampage.

Blackmailing a young couple to assist with his horrific experiments the Baron, desperate for vital medical data, abducts a man from an insane asylum. On route the abductee dies and the Baron and his assistant transplant his brain into a corpse. The creature is tormented by a trapped soul in an alien shell and, after a visit to his wife who violently rejects his monstrous form, the creature wreaks his revenge on the perpetrator of his misery: Baron Frankenstein.

Grave robbers open the grave of the wolf man and awaken him. He doesn't like the idea of being immortal and killing people when the moon is full so tries to find Dr. Frankenstein, in the hopes that the doctor can cure him. Dr. Frankenstein has died; however, his monster is found.

Victor Frankenstein is a promising young doctor who, devastated by the death of his mother during childbirth, becomes obsessed with bringing the dead back to life. His experiments lead to the creation of a monster, which Frankenstein has put together with the remains of corpses. It's not long before Frankenstein regrets his actions.

In the early 19th century, Dr. Frankenstein discovers the secret of life – how to create a perfect man – powerful, intelligent and immune to disease. But something goes wrong in the laboratory and the doctor’s hideous creation disappears into the night. At first, Frankenstein hoped that the horrible monster would perish in the wilderness, but now he senses that it’s alive and sets out for him. Dr. Frankenstein tracks the creature to the Arctic, where the two must battle to decide who will become the master of the other’s life…or death.

Within the decadent walls of the Frankenstein mansion, the Baron and his depraved assistant Otto have discovered the means of creating new life. As the Baron's laboratory begins to fill up with stitched body parts, the Baroness dallies with the randy new manservant and soon the decadent, permissive household is consumed by an outrageous, bizarre and hilarious combination of death and dismemberment.

An investigation into a serial killer leads two detectives to discover that Dr. Frankenstein and his creature are still alive after two centuries of genetic experiments.