Manhattan explores how the life of a middle-aged television writer dating a teenage girl is further complicated when he falls in love with his best friend's mistress.

A renowned ophthalmologist is desperate to cut off an adulterous relationship…which ends up in murder; and a frustrated documentary filmmaker woos an attractive television producer while making a film about her insufferably self-centered boss.

Early in the 20th century, middle-aged lawyer Fredrik Egerman and his young wife, Anne, have still not consummated their marriage, while Fredrik's son finds himself increasingly attracted to his new stepmother. To make matters worse, Fredrik's old flame Desiree makes a public bet that she can seduce him at a romantic weekend retreat where four couples convene, swapping partners and pairing off in unexpected ways.

Dorian and Angus chase down their womanizing stepfather with a helicopter, frightening him to death. In his effort to cover their tracks, Dorian begins investigating his stepfather's mistress, Sally. She works at a fast-food drive-through, she's pregnant and Dorian quickly falls in love with her. Unfortunately, his scheming mother wants Sally dead. And Sally isn't sure she wants Dorian to be her child's father and also his brother.

Robert Talbot, an American millionaire, arrives early for his annual vacation at his luxurious Italian villa. His long-time girlfriend Lisa has given up waiting for him and has decided to marry another man. Meanwhile, his sneaky business associate Maurice secretly misappropriates the villa as a hotel while Talbot is away. The current guests of the "hotel" are a group of young American girls.

A pathetic police chief, humiliated by everyone around him, suddenly wants a clean slate in life, and resorts to drastic means to achieve it.

The lives of several individuals intertwine as they go about their lives in their own unique ways, engaging in acts which society as a whole might find disturbing in a desperate search for human connection.

A seasoned enforcer is given the seemingly routine task of finding the Boss's runaway mistress, Kitty. However Kitty is involved in plans to overthrow the Boss and this routine task gets very complicated.

New York concierge Doug Ireland wants to go into business for himself and refurbish a hotel on Roosevelt Island, N.Y., but he needs an investor. With a few weeks left before his option on the site runs out, Doug agrees to help wealthy Christian Hanover conceal his affair with salesgirl Andy Hart from his wife. Despite his own attraction to Andy, Doug tries to stay focused on getting Christian to invest $3 million in his project.

Charles, an attorney, and Helen, his devoted wife, seem to have everything – money, a beautiful mansion – the American Dream. However, as Helen prepares to celebrate their 18th wedding anniversary, her life takes an unexpected twist when she comes home to find her clothes packed up in a U-Haul van parked in the driveway. Charles is divorcing her and kicks her out. Helen moves in with her grandmother Madea, an old woman who doesn't take any lip from anyone. Madea helps Helen through these tough times by showing her what is really important in life. Helen is forced to rediscover love, life, and religion in her pursuit for happiness.

Photographer Elliot Slater has inadvertently snapped the only existing photos of elusive jewel thief Omar. When Elliot leaves for a private vacation on an S&M island, he is followed by Omar, Omar's partner, Nina, and undercover police officers Fred and Sheila. Unaware of the number of people chasing him, Elliot enjoys his stay at the resort, and finds himself falling in love with head dominatrix Lisa.

Eight married college friends plus one other non-friend (all of whom have achieved middle to upper class economic status) go to Colorado for their annual week-long reunion, but the mood shifts when one couple's infidelity comes to light. As secrets are revealed, each couple begins to question their own relationship.