In Prohibition-era Chicago, musicians Joe and Jerry witness a mob hit, and flee the state in an all-female band disguised as Josephine and Daphne, but further complications set in.

With high school a distant memory, Jim and Michelle are getting married — and in a hurry, since Jim's grandmother is sick and wants to see him walk down the aisle — prompting Stifler to throw the ultimate bachelor party. And Jim's dad is reliable as ever, doling out advice no one wants to hear.

Everyone has 'moved on', except for Sherman and Jim Levenstein's still understanding father. Little Matt Stiffler wants to join his older brother Steve's business and, after everything Matt has heard from Jim's band-geek wife, he plans to go back to band camp and make a video of his own.

When Erik Stifler realizes that he's the only Stifler family member who might graduate high school a virgin, he decides to live up to his legacy. After some well-meaning advice from Jim's dad, Erik's ready to take his chances at the annual and infamous Naked Mile race, where his devoted friends and some uninhibited sorority girls will create the most outrageous weekend ever.

Erik, Ryan, and Cooze start college and pledge the Beta House fraternity, presided over by none other than legendary Dwight Stifler. But chaos ensues when a fraternity of geeks threatens to stop the debauchery and the Betas have to make a stand for their right to party.

Andy Stitzer has a pleasant life with a nice apartment and a job stamping invoices at an electronics store. But at age 40, there's one thing Andy hasn't done, and it's really bothering his sex-obsessed male co-workers: Andy is still a virgin. Determined to help Andy get laid, the guys make it their mission to de-virginize him. But it all seems hopeless until Andy meets small business owner Trish, a single mom.

A scientist discovers a way to turn cow manure into energy. Two secret agents are dispatched to find out the formula but they devote more time to having sex with each other than they do going after the scientist. Pretty soon everyone in the area is after the scientist but they also wind up spending more time having sex with each other.

Steven Russell leads a seemingly average life – an organ player in the local church, happily married to Debbie, and a member of the local police force. That is until he has a severe car accident that leads him to the ultimate epiphany: he’s gay and he’s going to live life to the fullest – even if he has to break the law to do it. Taking on an extravagant lifestyle, Steven turns to cons and fraud to make ends meet and is eventually sent to the State Penitentiary where he meets the love of his life, a sensitive, soft-spoken man named Phillip Morris. His devotion to freeing Phillip from jail and building the perfect life together prompts him to attempt (and often succeed at) one impossible con after another.

Rodolfo Persichetti has reached the maximum of his career and at the same time the minimum of his sexual capacities. A famous psychiatrist helps him in regaining his lost virility by mean of a new therapy.

Private-school student Christine loves Jim. But her classmate, Jordan, is also vying for Jim's attention and trying to end his relationship with Christine. Meanwhile, Jim's friend Bubba embarks on a series of sexual escapades, including dressing up as a woman to access the girls' locker room. Despite Jim and Christine's efforts to spend some time alone, various shenanigans and schemes interfere.

A guy starts a fake casting agency in hopes that he will meet his soul mate.

When a foreign-exchange student and a hooker - both named Dominique - show up on a college campus, the unsuspecting student body is in for the education of a lifetime!