A former sheriff relentlessly pursuing the 7 men who murdered his wife in Arizona crosses paths with a couple heading to California.

Bart Morgan controls the town of Cactus City and is keeping all men away from Jane Rankin. When Johnny Day arrives and takes an interest in Jane, Morgan tries to kick him out. Johnny refuses to go and the stage is set for a showdown.

After the Civil War, a former Union colonel searches for the two traitors whose perfidy led to the loss of a close friend.

After escaping from jail, outlaw Wes McQueen is convinced by his old partner in crime to do one last heist.

A sheriff tracking a gang of rustlers discovers that one of them is the brother of his fiance.

After killing Billy the Kid, Sheriff Pat Garrett is relentlessly dogged by members of the Kid's gang.

"Iron Mike" Haines (Tom Chatterton), a crooked sheriff, and "Hands" Weber (Roy Barcroft), the town blacksmith, are in cahoots and have been robbing stages, silver mines, etc., and framing innocent ranchers and cowhands with their deeds. They set out to rob the stage and frame Red Ryder (Bill Elliott as Wild Bill Elliott) for it, but the plan backfires and the sheriff is killed. The sheriff's son, Tommy (Jack McClendon), arrives home from college and is given his dad's job, not knowing he was a crook, and swears to get the man who killed him. Weber tells Tommy that Red killed his dad and Tommy sets out to get Red.

Stodge City is in the grip of the Rumpo Kid and his gang. Mistaken identity again takes a hand as a 'sanitary engineer' named Marshal P. Knutt is mistaken for a law marshal. Being the conscientious sort, Marshal tries to help the town get rid of Rumpo, and a showdown is inevitable. Marshal has two aids—revenge-seeking Annie Oakley and his sanitary expertise.

Curt Mason saves Doc Henderson's Medicine Show from being robbed by the Morrell gang but later earns the enmity of Carolyn when he blames the troupe for polluting a local watering hole. Arriving in town, the medicine show, which consists of Doc Henderson, Taffy, the singing group the Hoosier Hot Shots and Carolyn, begin their performance while Curt is unsuccessfully attempting to stop the Morrell gang from robbing the bank. The sheriff mistakes Curt for one of the gang, and to save their friend, Curt's buddies Biscuit and Big Boy stampede their cattle through town. In order to clear his good name, Curt and his friends go in search of the real bank robbers, who as it turns out are working under orders from Doc Henderson.

Convicted killer Jim Holden is rescued from the sheriff by his gang, led by Mason and Riley. He is out to get the Hathaway Stage superintendent George Bannister, who was responsible for his conviction and learns the Bannister, his niece (Kay) and Hal Hathaway, son of the stage line owner, are on a cross-country stage. Johnny, a rancher, and Waco, local stage representative head for the stage to warn the passengers, including entertainer Paradise Flo and coffin salesman Pennypacker. Hal takes the stage into Holdin. Johnny and Waco rescue Hal and Bannister before the gang succeeds in hanging the pair.

Newly appointed sheriff Pat Garrett is pleased when his old friend Doc Holliday arrives in Lincoln, New Mexico on the stage. Doc is trailing his stolen horse, and it is discovered in the possession of Billy the Kid. In a surprising turnaround, Billy and Doc become friends. This causes the friendship between Doc and Pat to cool. The odd relationship between Doc and Billy grows stranger when Doc hides Billy at his girl Rio's place after Billy is shot.

A Texan sheriff and his younger brother travel across the border into Mexico to confront the man who killed their father.