Black Jack is a master surgeon who possesses impeccable skills, enabling him to perform operations that are impossible for even the finest surgeons. He now is faced with his most difficult task to date and must challenge the limits of medical science...before it's too late!

Etsuro Kurosu faills getting into a university and becomes a hikikomori. One day, he tries to hang himself from a hook on the wall in his apartment. He fails, but his attempt leaves a hole in the wall. Through the hole wall, Etsuro Kurosu can now see Rio Miyaichi. He becomes fascinated with the girl that lives next door. Later, while peeping at her through the wall, Etsuro Kurosu sees her in the process of brutally murdering someone. He screams and is caught by her. Etsuro Kurosu confesses that he loves her and they start to date. Etsuro Kurosu feels happiness in his life, but what will happen to him? Will he be murdered by Rio Miyaichi?

In the late 1990s, society is descending into ecological collapse and totalitarianism. Saiga Riki-Oh, a mysterious man with a six-pointed star on his fist, finds himself at the privately-owned Tokyo State Prison. Serving a term of three years due to assault, his first offense, Riki-Oh openly antagonizes The Four Emperors, four powerful prisoners that control the prison and keep the rest of the inmates in line...

Ito is a second-year high school student and an only child who has to move to a different city; her mother remarried and begins her new life as an older sister of 4 siblings! The start of a family-love-comedy with four step-brothers!

The Japanese government carries out a program to increase the birth rate in the country. Their program analyzes gene information from its residents and selects a marriage partner for them. Aoi Nisaka is a high school student. She is in a love triangle with childhood friend Yuto Shiba and Sosuke Takachiho. Sosuke Takachiho is appointed by the government to become her husband.

In middle school, Futaba Yoshioka was madly in love with Tanaka Kou but he moves away with his mother. She is reunited with him later in life but he is not the same person anymore.

Ninako Kinoshita has never been in love until an encounter with the school's most popular boy, Ren Ichinose, leads the two to befriending each other. Ren's patient and kind personality is a far cry from his unapproachable idol status at school, and soon Ninako falls in love with him. However, she must cope with the fact that he already has a long-time girlfriend.

Kaisei Sakamoto is a 16 year old boy who is inclined to settle everything with his fists. He grew up in a town where you can see both Nagazaki and Gunkanjima, living with his father. His father, Genkai Sakamoto, runs a small ramen shop. The father-son duo has just recently had a large fight. The story showcases fragments of one's youth and the questions that crop up while growing up.

A group of students from the Cosmo Academy are about to take their final exam: surviving for over fifty days in a derelict ship. But when they arrive, they discover that instead of ten students, there are eleven. One of them doesn't belong there...

Second year high school student Kodaka Hasegawa has transferred to his new school about a month ago, but he still hasn't made any friends. Kodaka Hasegawa was born from a Japanese father and a British mother. Because of his appearance, people think Kodaka Hasegawa is a troubled kid. One day, Kodaka Hasegawa sees classmate Yozora Mikazuki pleasantly talking to herself. Kodaka Hasegawa talks with her about how to make friends. To make friends, Yozora Mikazuki decides to form the Neighbor's Club and forces Kodaka to enroll in the club.

A compilation film of the Thorny Arc, episodes 43–46 in the second season, featuring additional footage. The movie is a part of the "Gintama 20th Anniversary Project."

In a universe where the Cold War never ended and growing conflicts result in the rapid advancement of technological warfare, the cyborg spy Mylene Hoffman of the 00 Organization battles the agents of the Eastern block in a game of high tech espionage.