Raoul Duke and his attorney Dr. Gonzo drive a red convertible across the Mojave desert to Las Vegas with a suitcase full of drugs to cover a motorcycle race. As their consumption of drugs increases at an alarming rate, the stoned duo trash their hotel room and fear legal repercussions. Duke begins to drive back to L.A., but after an odd run-in with a cop, he returns to Sin City and continues his wild drug binge.

Aspiring Florida defense lawyer Kevin Lomax accepts a job at a New York law firm. With the stakes getting higher every case, Kevin quickly learns that his boss has something far more evil planned.

When actress Nikki Grace gets the lead role in a cursed film, her world becomes more and more surreal, blending realities and ideas of infidelity, reincarnation, and supernatural forces.

The murderous, backwoods Firefly family take to the road to escape the vengeful Sheriff Wydell, who is not afraid of being as ruthless as his target.

Blank-faced bug killer Bill Lee and his dead-eyed wife, Joan, like to get high on Bill's pest poisons while lounging with Beat poet pals. After meeting the devilish Dr. Benway, Bill gets a drug made from a centipede. Upon indulging, he accidentally kills Joan, takes orders from his typewriter-turned-cockroach, ends up in a constantly mutating Mediterranean city and learns that his hip friends have published his work -- which he doesn't remember writing.

Beautiful young manicurist Carole suffers from androphobia (the pathological fear of interaction with men). When her sister and roommate, Helen, leaves their London flat to go on an Italian holiday with her married boyfriend, Carole withdraws into her apartment. She begins to experience frightful hallucinations, her fear gradually mutating into madness.

A quiet and inconspicuous man rents an apartment in Paris where he finds himself drawn into a rabbit hole of dangerous paranoia.

A former circus artist escapes from a mental hospital to rejoin his armless, cult leader mother, and is forced to enact brutal murders in her name.

On the island of Cyprus, an insomniac is haunted by hallucinations that his mother believes are a message from his dead father.

After stealing a huge stash of drugs, speed freaks Hector and Dorena plan to cook up an enormous batch of crystal meth and get rich quick. Hector's old buddy Merle has the perfect hideout/meth lab: an old, abandoned farmhouse in the woods where no one will ever find them. Unfortunately, no one will hear their screams either. Turns out, they may not be alone after all. It seems this farmhouse is the site of a horrific urban legend. Now, holed up together with nothing to do but snort, smoke and shoot up, the strung-out "cookers" fall prey to paranoia, private demons and terrifying visions which, whether they are hallucinations or hauntings, are equally terrifying and just as deadly!

Beat Takeshi lives the busy and sometimes surreal life of a showbiz celebrity. One day he meets his blond lookalike named Kitano, a shy convenience store cashier, who, still an unknown actor, is waiting for his big break. After their paths cross, Kitano seems to begin hallucinating about becoming Beat.

13-year-old Rynn Jacobs lives in a New England beach town. Whenever the landlady inquires after Rynn's father, she claims that he's not available. But when the landlady's son, Frank, won't leave Rynn alone, she teams up with a neighbor Mario to maintain the dark family secret that she's been keeping to herself.