Raoul Duke and his attorney Dr. Gonzo drive a red convertible across the Mojave desert to Las Vegas with a suitcase full of drugs to cover a motorcycle race. As their consumption of drugs increases at an alarming rate, the stoned duo trash their hotel room and fear legal repercussions. Duke begins to drive back to L.A., but after an odd run-in with a cop, he returns to Sin City and continues his wild drug binge.

17 year old Nói drifts through life on a remote fjord in Iceland. In winter, the fjord is cut off from the outside world, surrounded by ominous mountains and buried under a shroud of snow. Nói dreams of escaping from this white-walled prison with Íris, a city girl who works in a local gas station. But his clumsy attempts at escape spiral out of control.

Chasing a memory, Alex is determined to drive cross-country to Melbourne. Planning on having just the highway for company, he reluctantly picks up a hitchhiker running from something with as much determination as Alex is running to something.

Almost casually, the young concrete worker Bastian kills a tramp. The police believe it was an accident and so the murder remains undiscovered for the time being.

On their way to an afternoon on the lake, husband and wife Andrzej and Krystyna nearly run over a young hitchhiker. Inviting the young man onto the boat with them, Andrzej begins to subtly torment him; the hitchhiker responds by making overtures toward Krystyna. When the hitchhiker is accidentally knocked overboard, the husband's panic results in unexpected consequences.

Following the arrest of her mother, Ramona, young Vanessa Lutz decides to go in search of her estranged grandmother. On the way, she is given a ride by school counselor Bob Wolverton. During the journey, Lutz begins to realize that Bob is the notorious I-5 Killer and manages to escape by shooting him several times. Wounded but still very much alive, Bob pursues Lutz across the state in this modern retelling of Little Red Riding Hood.

Due to a learning disability, Josie's life in a tiny town revolves around a menial job taking care of a garage that could close at any day. Things start to change, however, when David, the son of his boss' girlfriend, comes to work with him. Josie hangs out with David and his teenage friends, bringing them beer, and despite being a grown man himself, finds that the new company lifts his spirits. But his simple-mindedness blinds him to some potential legal dangers.

One year after running away from home, Nicole and Jesse are still missing. When Jesse's brother, Tom, returns home from active duty, he sets out with his friends Marilyn and Jared to locate the lost couple. Their search leads them to the stretch of old highway with a mysterious Rest Stop, where they find themselves in the same predicament as Nicole and Jesse: confronting a madman.

One evening, Hammer gives a ride to Christina, an attractive hitchhiker on a lonely country road, who has escaped from the nearby lunatic asylum. Thugs waylay them and force his car to crash. When Hammer returns to semi-consciousness, he hears Christina being tortured until she dies. Hammer, both for vengeance and in hopes that "something big" is behind it all, decides to pursue the case.

The life of Al Roberts, a pianist in a New York nightclub, turns into a nightmare when he decides to hitchhike to Los Angeles to visit his girlfriend.

A sadistic serial killer terrorizes a couple driving on a rural highway in Texas while killing numerous people and framing them for his killings.

Two hit men walk into a diner asking for a man called "the Swede". When the killers find the Swede, he's expecting them and doesn't put up a fight. Since the Swede had a life insurance policy, an investigator, on a hunch, decides to look into the murder. As the Swede's past is laid bare, it comes to light that he was in love with a beautiful woman who may have lured him into pulling off a bank robbery overseen by another man.