Four unwitting heroes cross paths on their journey to the sleepy town of Silverado. Little do they know the town where their family and friends reside has been taken over by a corrupt sheriff and a murderous posse. It's up to the sharp-shooting foursome to save the day, but first they have to break each other out of jail, and learn who their real friends are.

Buffalo Bill and Wild Bill Hickok join forces to establish a mail route that can get mail from St. Joseph, Missouri, to Sacramento, California, in ten days. Along the way they must battle bad weather, hostile Indians and outlaws intent on robbing the mail and shutting down the entire operation.

During a ride with his new pony Sinoya, the young Clay Gibson by chance finds the secret housing of the multiple murderer Tris Hatten. He reports immediately to Sheriff Adams, who strongly recommends him not to tell anybody about it. Unfortunately Clay talks to his father nevertheless. He believes Adams just wanted fame and reward for himself and accuses him in the newspaper. Thereby he endangers his son, who's now targeted by a killer which Tris' girlfriend Winnie hired for revenge. Written by Tom Zoerner

Temple Houston (Sam Houston's son) who is the DA with a sense of Justice. He is located in Fort Smith, Ark and works with Judge Parker in 1872. His area includes the Oklahoma Territory which was the Indian territory at that time. Chief Buffalo Horn who is falsely accused of murder.

It's just after the Civil War and Ben Shelby arrives looking for Johnny Tallon whom he plans to kill. Shelby was the only survivor of a battle due to the cowardice of Tallon. Thinking Tallon dead, another man who lost a brother at the same battle arrives to kill Tallon's blind brother. Tallon arrives to find Shelby and his brother fleeing. Then they are attacked by Indians and Shelby and Tallon must now fight together postponing the inevitable showdown.

A band of murderous cowboys has imposed a reign of terror on the town of Warlock. With the sheriff humiliatingly run out of town, the residents hire the services of Clay Blaisedell as de facto town marshal. He arrives along with his friend, Tom Morgan, and sets about restoring law and order on his own terms whilst also overseeing the establishment of a gambling house and saloon.

Wild Bill Hickok, Calamity Jane, and Buffalo Bill go up against Indians and a gunrunner.

Lawman Wyatt Earp and outlaw Doc Holliday form an unlikely alliance which culminates in their participation in the legendary Gunfight at the O.K. Corral.

Cole Thornton, a gunfighter for hire, joins forces with an old friend, Sheriff J.P. Harrah. Together with a fighter and a gambler, they help a rancher and his family fight a rival rancher that is trying to steal their water.

An experienced bounty hunter helps a young sheriff learn the meaning of his badge.

A small-town sheriff in the American West enlists the help of a disabled man, a drunk, and a young gunfighter in his efforts to hold in jail the brother of the local bad guy.

Robert Ryan plays an aging sheriff responsible for law and order in a frontier cattle town. Virginia Mayo plays his fiancee. As if handling wild cattle drovers isn't enough, a crooked casino operator from Ryan's past comes to town. An early scuffle in the casino leaves Ryan with vision problems that interfere with his duties. Jeffrey Hunter who came to town with a cattle drive encounters Ryan, who killed Hunter's father when Hunter was young. Feelings of animosity soon change as Hunter begins to sense Ryan is telling the truth about his father. What follows is a plot that continues to thicken to the inevitable showdown.