Raoul Duke and his attorney Dr. Gonzo drive a red convertible across the Mojave desert to Las Vegas with a suitcase full of drugs to cover a motorcycle race. As their consumption of drugs increases at an alarming rate, the stoned duo trash their hotel room and fear legal repercussions. Duke begins to drive back to L.A., but after an odd run-in with a cop, he returns to Sin City and continues his wild drug binge.

Rufus is a dog but turns into a human with a pendant. He meets a girl named Kat who asks him to go out. Kat is a cat who can also turn into a human as well.

37-year-old Italian-American widow Loretta Castorini believes she is unlucky in love, and so accepts a marriage proposal from her boyfriend Johnny, even though she doesn't love him. When she meets his estranged younger brother Ronny, an emotional and passionate man, she finds herself drawn to him. She tries to resist, but Ronny, who blames his brother for the loss of his hand, has no scruples about aggressively pursuing her while Johnny is out of the country. As Loretta falls for Ronny, she learns that she's not the only one in her family with a secret romance.

When architect Alex Wyler moves into an unusual glass house on stilts over a lake, he discovers a note from the previous tenant in the mailbox--but no one's lived in the house for years. He replies and soon discovers that he's corresponding with a doctor named Kate Forster. Their correspondence, only through the 'magical' mailbox, turns romantic and their paths cross in unexpected ways, but when they try to truly connect, danger looms. They must try to unravel the mystery behind their extraordinary romance before it's too late.

Abandoned by his owners, a feisty and playful dog joins a pack of strays and embarks on a journey filled with fun and life lessons in their pursuit to find a new and loving home.

Forced by his son's birthday wish, fast-talking attorney and habitual liar Fletcher Reede must tell the truth for the next 24 hours.

A misanthropic author, a single mother and waitress, and a gay artist form an unlikely friendship after the artist is assaulted in a robbery.

Tabloid reporters are sent by their editor to investigate after the paper recieves a letter from a woman claiming an angel is living with her.

A young couple discovers a secret room filled with cash while house-sitting for rich friends who die while out of the country.

A husband and wife detective team takes on the search for a missing inventor and almost get killed for their efforts.

Baby Dumpling, the six-year-old son of Blondie and Dagwood Bumstead disappears from sight during his first day at school. While Dagwood frantically combs the city in search of the boy, Baby Dumpling spents a nice, safe afternoon with poor little rich girl Melinda Mason, who with her new playmate's help arises from her sickbed to walk across the room for the first time in months.

Blondie and Dagwood are in charge of operations at a mountain motel. The elderly owners of the establishment are in danger of losing their life savings. Among other things, arson threatens.