Harold Crick is a lonely IRS agent whose mundane existence is transformed when he hears a mysterious voice narrating his life.

Writer Harry Block draws inspiration from people he knows, and from events that happened to him, sometimes causing these people to become alienated from him as a result.

Charlie Kaufman is a confused L.A. screenwriter overwhelmed by feelings of inadequacy, sexual frustration, self-loathing, and by the screenwriting ambitions of his freeloading twin brother Donald. While struggling to adapt "The Orchid Thief," by Susan Orlean, Kaufman's life spins from pathetic to bizarre. The lives of Kaufman and Orlean's book become strangely intertwined as each one's search for passion collides with the other's.

Over a single summer day in New York, the lives of two mothers briefly entwine. Julia, a writer and mother, is unsettled by creative stagnation, unprocessed grief, and the approach of her daughter’s adolescence. An unexpected encounter with Taylor—a labor and delivery nurse in the midst of a postpartum crisis—pushes Julia to reconsider the life she has built, and whether she can rediscover herself within it.

Jack Manfred is an aspiring writer who to make ends meet, takes a job as a croupier. Jack remains an observer, knowing that everything in life is a gamble and that gamblers are born to lose. Inevitably, he gets sucked into the world of the casino which takes its toll on his relationships and the novel he is writing.

Abhimanyu Roy is stuck with writer's block until he decides to re-live the memories of his childhood sweetheart Bindu who aspires to be a successful singer and struggles to give Abhi the one thing he craves - stability.

Besieged by writer’s block and the crushing breakup with Tessa, Hardin travels to Portugal in search of a woman he wronged in the past – and to find himself. Hoping to win back Tessa, he realizes he needs to change his ways before he can make the ultimate commitment.

Emma approaches adulthood, she tries to live an ordinary life and keep up to her late mothers expectations. However her anxiety weighs over her, stopping her from enjoying the last few youthful years.

Guido, an acclaimed writer, leads a seemingly perfect life with his wife and daughter, but his restless search for inspiration leads him into the arms of Giulia, a charming and mysterious swim instructor who's hiding a secret.

At a remote lake house in the Adirondack Mountains, a couple entertains an out-of-town guest looking for inspiration in her filmmaking. The group quickly falls into a calculated game of desire, manipulation, and jealousy, unaware of how dangerously intertwined their lives will soon become.

It sounds like a budding writer's dream: a bestselling first novel, a luxurious house in Malibu, and a trophy wife... But it all unravels when writer's block and a failed marriage send Richard McMurray out into the streets.

Hard-drinking novelist Zach Hutton spirals out of control after his wife and mistress both leave him. Alone and crippled by a bad case of writer's block, Zach slips in and out of casual relationships and one-night stands, while his drinking becomes more and more severe. With the help of a bartender and his therapist, Zach confronts his demons — women and alcohol.