Lorenzo Odone, a Virginia 5-year-old, develops a degenerative nerve disease so rare that nobody is working on a cure, so his parents decide to immerse themselves in research and tackle the problem themselves.

Grace Ainsworth wants to return to her career as an opera singer, and her mother-in-law supports her. Grace's husband, Edwin, wants her to stay at home and to convince her, he relates the story of his latest play about a man who allows his wife to return to the stage. Edwin comes to believe that Grace is in love with Harold Chase, a manager, and the couple separates. Edwin has an affair with a dancer, Madeline, and he winds up in a fight with her dancing partner, Vincenti, which causes him to lose his memory.

A man is shipwrecked on a South Seas island, and although he has a fiancee back home, he falls in love with a Polynesian girl. When his fiancee finally finds him and arrives on the island to take him home, she finds out that he refuses to leave the local girl, who is now the mother of his child.

The plot concerns a war hero who returns home determined to give up his old ways as a crook. Bud Doyle (Milton Sills) is still being hounded by the cops, and both his wife (Marcia Nanon) and a former associate, a dishonest politician, want to do him in.

After the death of a United States Senator, idealistic Jefferson Smith is appointed as his replacement in Washington. Soon, the naive and earnest new senator has to battle political corruption.

In the early 1960s, teenager Adam Stafford (Cameron Bright) becomes obsessed with his new neighbor, Catherine Caswell (Gretchen Mol), a divorcée and free spirit. Stafford spies on Caswell as she meets with strange men, and, despite the warnings of his conservative parents, he begins working for her as a gardener. Amid rumors of her affair with President Kennedy, the two become close, but political intrigue surrounding her acquaintances soon infringes on their friendship.

In a jealous rage dancer Anna Janssen shoots her common-law husband Alastair De Vries in a cafe when she discovers him with a chorus girl. Fleeing to Tahiti she is tracked by detective Thomas McCarthy who arrests her. On their return journey they are marooned on a deserted island. After 2 years together, they realize their love and take marriage vows, but when a ship is sighted, she insists, against his wishes, that she return to face trial.

Minister John Hodder becomes rector of a prestigious church in the Midwestern city of Bremerton but finds dissension and malfeasance among his congregation. When he calls it out both tragedy and a way forward are revealed.

Two Navy men are ordered to bring a young offender to prison, but decide to show him one last good time along the way.

Barbara Rand is blinded when she leaps through a window to escape an assailant. Her sister, Natalie, reluctantly abandons her fiancé, Ned Gardiner, and marries Oliver Landis, who can provide the money needed for Barbara's operation. Unaware that Oliver was Barbara's attacker, Natalie blames his business partner, Howard Pollard, who was with Barbara on the night she was injured. Natalie holds Howard at gunpoint, but when her husband arrives, he promises to deal with the villain making sure Howard falls to his death. Upon Barbara’s release from the hospital, Oliver tries to blind her once. Natalie threatens him with a pistol, but Oliver wrests it away from her. He then realizes that he can no longer hide his guilt from Natalie or the police and shoots himself. Barbara has been avenged, and Natalie is free to marry Ned.

A gangster running a protection racket gets information that he's about to be prosecuted on income-tax-evasion charges. He hires a man with a photographic memory to memorize his books, then destroys them all so the police won't have any evidence to link him to the racket.

James “Brick” Davis, a struggling attorney, owes his education to a mobster, but always has refused to get involved with the underworld. When a friend of his is gunned down by a notorious criminal, Brick decides to abandon the exercise of the law and join the Department of Justice to capture the murderer.