A group of people traveling on a stagecoach find their journey complicated by the threat of Geronimo, and learn something about each other in the process.

The town of Primrose, Arizona is beset by outlaws, so the towns people hire Fletcher Bissell III (A.K.A. The Silver Dollar Kid) as their new sheriff. Fletcher is so cowardly the townsfolk are sure that the local outlaws will be too proud to gun him down. This proves to be the case, and the outlaws hire their own cowardly gunfighter, Chicken Finsterwald, to go up against The Silver Dollar Kid.

A government agent uncovers the truth behind a series of raids on a freight company.

In Arizona in the late 1800s, infamous outlaw Ben Wade and his vicious gang of thieves and murderers have plagued the Southern Railroad. When Wade is captured, Civil War veteran Dan Evans, struggling to survive on his drought-plagued ranch, volunteers to deliver him alive to the "3:10 to Yuma", a train that will take the killer to trial.

Phoebe Titus is a tough, swaggering pioneer woman, but her ways become decidedly more feminine when she falls for California bound Peter Muncie. But Peter won't be distracted from his journey and Phoebe is left alone and plenty busy with villains Jefferson Carteret and Lazarus Ward plotting at every turn to destroy her freighting company. She has not seen the last of Peter, however.

In the midst of some friendly horseplay on their "Flying R" ranch, the Range Busters, Crash Corrigan, Dusty King and Alibi Terhune, are sobered by the arrival of a buckboard bearing their old friend Larry Meadows and his niece Dorrie Willard. Meadows seeks their aid against a gang of outlaws terrorizing his town. Ernie Willard, Dorrie's brother, has been taken in by Tex Laughlin who is using the Willard ranch as an undercover for his real occupation as a member of a gang of outlaws led by Tim Douglas, a supposed friend of the Willards.

Roy Rogers is a cowboy who joins the Border Patrol, only to have his buddy Tommy get killed at a local saloon. Determined to get revenge at any cost, Roy and Rusty cross the border in search of Arizona Jack, the man responsible for Tommy's death.

Marshal Wyatt Earp kills a couple of men of the Clanton-gang in a fight. In revenge Clanton's thugs kill the marshal's brother. Thus, Wyatt Earp starts to chase the killers together with his friend Doc Holliday.

Having been a spy for Quantrill's raiders during the Civil War, Jeff Travis thinking himself a wanted man, flees to Prescott Arizona where he runs into Jules Mourret who knows of his past. He takes a job on the stage line that Mourret is trying to steal gold from. When Mourret's men kill a friend of his he sets out to get Mourret and his men. When his plan to have another gang get Mourret fails, he has to go after them himself.

After a stagecoach holdup, Frank Slayton's notorious gang leave Ben Warren for dead and head off with his fiancée. Warren follows, and although none of the townspeople he comes across are prepared to help, he recruits two others who have sworn revenge on the ruthless Slayton.

Fidencio Borer, an apothecary in a village on the northern border of Mexico, discovers some old title of a mine in Arizona and decides to claim them. Trying to cross the border is a border guard intercepted by exaggerating in the line of duty. On the way is captured by a tribe of Apaches and is about to be burned alive, but thanks to the Great Head Horse Lying having toothache and learns that the prisoner it can heal, ordered his release on the condition that the cure. Fidencio would take the wheel and gets the eternal friendship of the Chief apache.

Two cowboys, both former outlaws, are forced to find their way home after their camp is raided by the Dust Devils. On their journey to a new camp in Arizona, they must evade both the law and the Dust Devils across Colorado.