The event of the century is about to take place, a spectacular total solar eclipse. A girl is going to witness it with her grandmother and, despite her happiness, she will have to face her fear of the dark to enjoy the moment when it gets dark in the middle of the day. But when that happens, both of them will understand that sometimes the mind is also overshadowed by a reality that can erase all its memories.

Fiona and Grant have been married for nearly 50 years. They have to face the fact that Fiona’s absent-mindedness is a symptom of Alzheimer’s disease. She must go to a specialized nursing home, where she slowly forgets Grant and turns her affection to Aubrey, another patient in the home.

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A sister and brother face the realities of familial responsibility as they begin to care for their ailing father.

Two strangers, both at the end of their rope, suddenly meet in the middle of the unpredictable waters of Lake Michigan.

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For years, Axel has cut off ties with his family, devastated by a tragedy for which he was made to bear responsibility. When the freighter on which he was cook stopped in his hometown, he decided to visit his mother, Françoise. It's a shock: she no longer recognizes him. Having Alzheimer's disease, Françoise now forgets whole sections of her life. Axel is the first of the siblings to disappear from his memory. Why him? What is he hiding behind this oversight? And while Ivan and Lucie have agreed to have her admitted in the center, Axel opposes it frontally and delays her departure to take care of her, despite the tensions. Between the mother and the son opens the face-to-face so long feared and yet necessary.

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Although barely 30, Claire believes she is showing the first symptoms of Alzheimer's disease, a condition from which her mother has recently died. Her sister, Nathalie, is certain that her memory loss, caused by a lightning strike, is temporary. In the clinic where she is being treated, Claire is attracted to Philippe, a man who is still traumatized after a car accident in which his wife and child were both killed. In spite of their personal tragedies, Claire and Philippe fall in love. When Philippe recovers, Claire moves into his home. Then Claire's condition takes a turn for the worse.

With Christmas Eve just around the corner in bustling New York, five lonely and sad strangers find their lives inadvertently intersected.

Martin, conductor of a symphonic orchestra, meet Barbara, violine player and they start a relationship. Five years later Martin starts to develop loss of memory and becomes more and more confused. Finally he is diagnosed with Alzheimer's disease and Barbara tries to help as much as possible although Martin is often angry and violent towards her.

A runaway couple go on an unforgettable journey from Boston to Key West, recapturing their passion for life and their love for each other on a road trip that provides revelation and surprise right up to the very end.