The epic tale of the development of the American West from the 1830s through the Civil War to the end of the century, as seen through the eyes of one pioneer family.

In the 1870s, two rival businessmen, Zack Thomas and Joe Jarrett, on a stagecoach heading to Galveston, Texas, must pull together to protect $100,000 from an outlaw named Matson. Once in Galveston, however, their rivalry continues, as Thomas joins up with Elya Carlson and Jarret with Maxine Richter. But Matson is still on the loose, and a scheming banker threatens both Thomas and Jarrett.

After robbing a bank Murphy assumes the identity of his pursuer, a famous US Marshal, when he stumbles into a town and is confronted by the local judge, Matthau. Murphy is forced to remain as the new Marshal; an old flame, Scala, nearly unmasks him by accident, only to be forced to assume the ruse of being Murphy's wife. The "couple" given a house and respectability, which neither has had before. They maintain the charade to avoid hurting a young orphan boy, Matthau's ward. Scala is torn by her loyalty to boyfriend planning to rob the bank and growing feelings for Murphy

Two tough Kentucky mountaineers join a trading expedition from St. Louis up the Missouri River to trade whisky for furs with the Blackfoot Indians. They soon discover that there is much more than the elements to contend with.

A dream vacation of a lifetime quickly turns into a hijacking, endangering passengers and crew, on a boat journey down the Amazon River and into the Brazilian rainforest. Desperate criminals storm aboard, pursuing a lost fortune in the jungle. Now under threat, and with food and fuel running low, the once idealistic tourists - now hostages - must use all their ingenuity as their Amazon cruise becomes a descent into a desperate struggle for survival.

Virginia, 1803. After the United States of America acquires the inmense Louisiana territory from France, a great expedition, led by William Lewis and Meriwether Clark, is sent to survey the new lands and go where no white man has gone before.

In this biopic, Jim Bowie goes to New Orleans, where he falls for Judalon and befriends her brother, Narcisse. Soon, Jim is forced to avenge Narcisse's murder, but Judalon takes up with another man. Jim eventually has another romantic interlude with Judalon and is forced to kill one of her suitors in self-defense. Jim leaves town, and falls for the daughter of a Texas politician, but his entanglement with Judalon continues to bedevil him.

In the 1850s, in a logging town on the Mississippi River, a conflict between the people of a mill town and the lumberjacks who work downriver. Romance and deceit are catalyzed by the arrival of the gambling river boat, River Lady, owned by the beautiful Sequin. Bauvais, a representative of the local lumber syndicate and Sequin's business partner, is trying to convince H.L. Morrison, the mill owner, to sell his business.

Mark Fallon, with partner Kansas John Polly, tries to introduce honest gambling on the riverboats. His first success makes enemies of the crooked gamblers and of fair Angelique Dureau, whose necklace he won. Later in New Orleans, Mark befriends Angelique's father, but she still affects to despise him as his gambling career brings him wealth. Duelling, tragedy, and romantic complications follow.

Lambert owns the trucking line that ships cattle to market. When he raises his rates Roy decides to ship the cattle on the River Boat. When Lambert and his men are unable to stop the boat, they rustle the cattle.

Ben Matthews gives up the flashy life of a riverboat gambler, hoping to settle down in Galena with his girlfriend, luscious entertainer Zoe. But Galena's leading citizen is murdered on the boat; Ben, on arrival, finds a lynch mob after his neck, and flees. Three years of wandering later, Zoe's letters stop coming and Ben returns to find her and attempt the hopeless task of clearing himself.

Two American gun runners at odds with each other and looking to sell guns to the rebels during the Cuban War of Independence navigate a boat to Cuba. Along for the ride is a beautiful Cuban rebel in who both men are interested.