In post-9/11 New York City, an eclectic group of citizens find their lives entangled, personally, romantically, and sexually, at Shortbus, an underground Brooklyn salon infamous for its blend of art, music, politics, and carnality.

Anne, a newcomer to the workplace, was asked to deliver some documents to the CEO's house. However, she accidentally walked into the president's private SM game room. Before she could react, CEO Earl caught her in the act.

Erika Kohut, a sexually repressed piano teacher living with her domineering mother, meets a young man who starts romantically pursuing her.

Vittorio, an American novelist teaching in Rome, meets the beautiful but damaged Bianca and they rapidly fall into an urgent, tempestuous affair. He's hesitant over their relationship since she seems to thrive on conflict and is constantly baiting him into physical altercation. Bianca gives Vittorio an exquisite leather belt as a gift; he knows immediately that she wants him to whip her with it. Driven by his craving for her, Vittorio complies to Bianca's desire. Their relationship escalates into a dark realm of S&M which becomes more and more self-destructive.

Murphy is an American living in Paris who enters a highly sexually and emotionally charged relationship with the unstable Electra. Unaware of the seismic effect it will have on their relationship, they invite their pretty neighbor into their bed.

A young woman, recently released from a mental hospital, gets a job as a secretary to a demanding lawyer, where their employer-employee relationship turns into a sexual, sadomasochistic one.

Connor has a threesome with his long-time crush Olivia and an alluring stranger named Jenny. It surprisingly serves as the spark to a full blown relationship with Olivia, until both women end up pregnant and all three are thrust into a difficult journey toward new realities that none of them could have expected.

Christina's love life is stuck in neutral. After years of avoiding the hazards of a meaningful relationship, one night while club-hopping with her girlfriends, she meets Peter, her perfect match. Fed up with playing games, she finally gets the courage to let her guard down and follow her heart, only to discover that Peter has suddenly left town. Accompanied by Courtney, she sets out to capture the one that got away.

A young couple finds themselves lost in their own relationship. Brought to frustration and confusion one of them shares the idea of an open relationship. Reluctantly the partner agrees and actually travels a new road learning about themself. Perhaps they just needed to find each other, in someone new.

The wealthy president of a company has built up an unpayable debt to a local crime lord, and to escape punishment he sells his famous dancer wife to the lecherous old man figuring a 90 year old can’t do too much bad with her. Perhaps not, but others can while he watches. She’s put on stage in an underground BDSM sex show and begins a spiraling decent from strongly independent woman to submissive sex slave

A gay couple realizes they aren't sexually compatible, so they look for a third man. But when betrayal and jealousy sneak in, their relationship shatters into pieces.

Laura and Massimo are back and hotter than ever. But the reunited couple's new beginning is complicated by Massimo’s family ties and a mysterious man who enters Laura’s life to win her heart and trust, at any cost.