Sherlock Holmes investigates a series of so-called "pajama suicides". He knows the female villain behind them is as cunning as Moriarty and as venomous as a spider.

When a bored Sherlock eagerly takes the case of Gabrielle Valladon following an attempt on her life, the search for her missing husband leads to Loch Ness and the legendary monster.

Arthur Conan Doyle reveals the story behind Sherlock Holmes and his mysteries by telling about Dr. Joseph Bell, from whom he drew his inspiration, after meeting him as a medical student in Edinburgh. This TV movie served as the pilot for the later released minisseries Murder Rooms: Mysteries of the Real Sherlock Holmes produced by the BBC. The series then picks up with Sir Arthur Conan Doyle's time as a general practitioner in Southsea, solving mysteries with the help of his mentor, Dr Joseph Bell, who is still based in Edinburgh.

Two dubious characters disguise themselves as Holmes and Watson to gain attention and end up chasing counterfeiters and stolen stamps.

In London, a secret society led by lawyer Thaddeus Merrydew collects the assets of any of its deceased members and divides them among the remaining members. Society members start dropping like flies. Sherlock Holmes is approached by member James Murphy's widow, who is miffed at being left penniless by her husband. When Captain Pyke is shot, Holmes keys in on his mysterious Chinese widow as well as the shady Merrydew. Other members keep dying: Malcom Dearing first, then Mr. Baker. There is also an attempt on the life of young Eileen Forrester, who became a reluctant society member upon the death of her father. Holmes' uncanny observations and insights are put to the test.

Now a detective-for-hire like her infamous brother, Enola Holmes takes on her first official case to find a missing girl, as the sparks of a dangerous conspiracy ignite a mystery that requires the help of friends — and Sherlock himself — to unravel.

When a nobleman is threatened by a family curse on his newly inherited estate, detective Sherlock Holmes is hired to investigate.

Sherlock Holmes and Dr. Watson meet as boys in an English Boarding school. Holmes is known for his deductive ability even as a youth, amazing his classmates with his abilities. When they discover a plot to murder a series of British business men by an Egyptian cult, they move to stop it.

Sherlock Holmes has retired. But when MacDonald asks him to take on another case, he says yes. There have been some mysterious murders, and there are no visible causes for the deaths. At the same time Holmes gets this case, Graf Udo Von Felseck gives him another case: find a young and missing prince to prevent war between Germany and England. But Von Felseck is not as honest as he seems...

Concerned about his friend's cocaine use, Dr. Watson tricks Sherlock Holmes into travelling to Vienna, where Holmes enters the care of Sigmund Freud. Freud attempts to solve the mysteries of Holmes' subconscious, while Holmes devotes himself to solving a mystery involving the kidnapping of Lola Deveraux.

The sensational details of a gruesome murder in The Daily Gazette have London in a panic, as a blood-thirsty madman - more vicious than Jack the Ripper - preys upon the city. Of greater concern to Scotland Yard, however, is that the account of the murder was published nearly two hours prior to the crime having been committed! Sherlock Holmes and Dr. Watson - the Great Detective and his faithful assistant and chronicler - find themselves challenged with one of their most baffling cases - "The Case of the Woman Who Was Murdered Tomorrow"! Will an innocent man be sent to the gallows? How much blood will be shed before a scarred fiend is brought to justice? ...And who are the mysterious Shadow Watchers, a coven of ominous figures who orchestrate terror from within the darkness? Starring Anthony D.P. Mann as Holmes and Terry Wade as Dr. Watson, "Sherlock Holmes and the Shadow Watchers" is a horrifying new adventure, produced with the kind permission of the Conan Doyle Estate*.

Holmes and Watson board a passenger train bound from London to Edinburgh, to guard the Star of Rhodesia, an enormous diamond worth a fortune belonging to an elderly woman of wealth; but within the first hour of the trip, the woman's son is murdered and the diamond stolen and any of the passengers in their car could be the killer thief.